Propargyl-PEG2-amine

≥ 95.0 %

10 mm in DMSO

Colorless to almost colorless clear liquid

Store at -20 °C, keep in dry and avoid sunlight.

Room temperature, or blue ice upon request.

2-(2-prop-2-ynoxyethoxy)ethanamine

Alkyne-PEG2-Amine;2-[2-(2-Propynyloxy)ethoxy]ethylamine; Propyne-PEG2-NH2; 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

213.8±20.0 °C at 760 mmHg

1.0±0.1 g/cm3

GVHLQHHQXWSDDM-UHFFFAOYSA-N

InChI=1S/C7H13NO2/c1-2-4-9-6-7-10-5-3-8/h1H,3-8H2

C#CCOCCOCCN

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2- amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.