Name: Propargyl-PEG2-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥ 95.0 %

Solubility

10 mm in DMSO

Appearance

Colorless to almost colorless clear liquid

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Shipping

Room temperature, or blue ice upon request.

IUPACName

2-(2-prop-2-ynoxyethoxy)ethanamine

Synonyms

Alkyne-PEG2-Amine;2-[2-(2-Propynyloxy)ethoxy]ethylamine; Propyne-PEG2-NH2; 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

Boiling Point

213.8±20.0 °C at 760 mmHg

Density

1.0±0.1 g/cm3

InChI Key

GVHLQHHQXWSDDM-UHFFFAOYSA-N

InChI

InChI=1S/C7H13NO2/c1-2-4-9-6-7-10-5-3-8/h1H,3-8H2

SMILES

C#CCOCCOCCN

Biological Activity

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2- amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	6.9842 mL	34.9211 mL	69.8422 mL
5 mM	1.3968 mL	6.9842 mL	13.9684 mL
10 mM	0.6984 mL	3.4921 mL	6.9842 mL

Propargyl-PEG2-amine is a PEG-based bifunctional linker designed for modular assembly of PROTACs, enabling efficient spatial separation between a target-binding ligand and an E3 ligase recruiter. Its ether-rich chain provides conformational flexibility and improved solubility, while the terminal alkyne handle supports orthogonal conjugation strategies. These features make it a practical building block for constructing targeted protein degraders, with detailed structural and synthetic considerations provided below.

Structure: The molecule contains a short poly(ethylene glycol) ether segment linked to a primary amine and a propargyl (terminal alkyne) functionality. It features C–N and C–C bonds, ether linkages, and an alkyne capable of selective coupling. The PEG segment imparts hydrophilicity and flexible, solvated conformations.

Reactivity: The terminal alkyne enables click-type conjugations and related alkyne-reactive chemistries, typically proceeding via copper-catalyzed azide–alkyne cycloaddition or catalyst-free variants depending on the partner. The primary amine can be used for amide formation, carbamate/urea coupling, or reductive amination to connect PROTAC fragments. Common approaches use standard coupling reagents in polar organic or mixed solvent systems under conditions compatible with sensitive ligands.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂