Name: Mal-amido-PEG2-TFP ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

(2,3,5,6-tetrafluorophenyl) 3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoate

Synonyms

MAL-PEG2-TFP ester; Mal-NH-PEG2-TFP; 2,3,5,6-tetrafluorophenyl 3-(2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethoxy)propanoate; Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-, 2,3,5,6-tetrafluorophenyl ester

Boiling Point

640.1±55.0°C at 760 mmHg

Density

1.414±0.1 g/cm3

InChI Key

HHXSYLTYQVHXMA-UHFFFAOYSA-N

InChI

InChI=1S/C20H20F4N2O7/c21-12-11-13(22)19(24)20(18(12)23)33-17(30)4-7-31-9-10-32-8-5-25-14(27)3-6-26-15(28)1-2-16(26)29/h1-2,11H,3-10H2,(H,25,27)

SMILES

C1=CC(=O)N(C1=O)CCC(=O)NCCOCCOCCC(=O)OC2=C(C(=CC(=C2F)F)F)F

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.0992 mL	10.4958 mL	20.9916 mL
5 mM	0.4198 mL	2.0992 mL	4.1983 mL
10 mM	0.2099 mL	1.0496 mL	2.0992 mL

This Mal-amido-PEG2-TFP ester is a bifunctional PROTAC linker designed to connect a maleimide-bearing handle with an activated carboxylate for efficient conjugation. Its PEG spacer supports favorable solubility and conformational flexibility, while the TFP ester enables rapid acylation of nucleophilic groups on targeting ligands. The combination of orthogonal reactivity makes it suitable for assembling targeted protein degradation constructs; the detailed structural and reactivity features are described below.

Structure: The linker contains a maleimide moiety for chemoselective Michael-type addition, an amide linkage, and a short polyethylene glycol spacer that increases hydrophilicity. An activated TFP ester provides an electrophilic carbonyl for acyl transfer, with stable covalent bonds formed upon conjugation.

Reactivity: Use the TFP ester for coupling to primary amines or other suitable nucleophiles under mild, anhydrous-to-semi-aqueous conditions, typically with base to promote nucleophile activation. The maleimide reacts via Michael addition with thiols (or thiol-containing ligands) to form a stable thioether. Perform sequential or orthogonal conjugations by controlling order, pH, and solvent compatibility; common coupling solvents include DMF or DMSO, with careful exclusion of competing thiols during TFP activation.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂