Mal-PEG2-acid
CAS No.: 1374666-32-6
Cat No.: BP-500326
Purity: ≥95%
4.5 
Mal-PEG2-acid is a heterobifunctional polyethylene glycol linker featuring a maleimide group for chemoselective conjugation to thiols and a terminal carboxylic acid that enables subsequent coupling, handle functionalization, or incorporation into PROTAC architectures. Structurally, it comprises a short PEG spacer that provides aqueous solubility and conformational flexibility while maintaining a defined distance between the reactive maleimide moiety and the acidic terminus. In PROTAC design, the maleimide can be used to attach to cysteine-containing ligands or engineered protein targets through fast, selective thio-Michael addition, forming a stable thioether linkage. The PEG spacer helps reduce steric constraints and can improve effective engagement between the two binding elements of the degrader. This linker is valuable for constructing targeted protein degradation reagents where controlled tethering, modular synthesis, and reliable conjugation chemistry are required for systematic structure–activity studies.
Structure of 1374666-32-6
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This Mal-PEG2-acid linker is designed for efficient conjugation in targeted protein degradation workflows, enabling modular assembly of PROTACs that connect a ligand-binding warhead to an E3-recruiting module. Its PEG-based spacer supports favorable solubility and conformational flexibility, while the maleimide functionality provides a robust handle for selective coupling to thiol-bearing partners under mild conditions. The detailed structural and reactivity considerations are provided below.
Structure: The linker is a maleimide-terminated PEG spacer bearing a terminal carboxylic acid. It contains a PEG ether chain, a conjugated maleimide ring, and an acid-bearing functional group. The combination supports water compatibility, stable covalent adduct formation, and straightforward downstream coupling chemistry.
Reactivity: Maleimides typically undergo chemoselective Michael-type addition with thiols to form stable thioether linkages. For PROTAC assembly, thiol-containing ligands are reacted with the maleimide linker in aqueous or mixed solvents under near-neutral conditions, often with controlled pH to preserve thiol nucleophilicity. No special catalysts are generally required; however, freshly prepared thiols and exclusion of competing thiol impurities are commonly used to drive selectivity and completion.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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