Name: Hydroxy-PEG5-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

OH-PEG5-COOH; HO-PEG5-Propionic acid; HO-PEG5-CH2CH2COOH; Hydroxy-PEG5-propionic acid; 1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid; Propanoic acid, 3-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-; 3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-hydroxy-

Boiling Point

455.7±45.0°C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

NQZLSNLBIKBFNP-UHFFFAOYSA-N

InChI

InChI=1S/C13H26O8/c14-2-4-18-6-8-20-10-12-21-11-9-19-7-5-17-3-1-13(15)16/h14H,1-12H2,(H,15,16)

SMILES

C(COCCOCCOCCOCCOCCO)C(=O)O

Hydroxy-PEG5-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to provide a hydrophilic, flexible spacer between a ligand and a recruiting moiety. Its terminal carboxylic acid enables robust conjugation strategies commonly used to assemble targeted protein degraders, while the ether-rich PEG segment helps modulate solubility and spatial presentation in ternary complex formation. The detailed structural and synthetic considerations are provided below.

Structure: The linker contains a PEG backbone composed of repeating ether units, terminating in a carboxylic acid functionality and a hydroxyl group. It features flexible C–O ether linkages that confer conformational mobility and strong hydrogen-bonding capacity, supporting favorable aqueous compatibility.

Reactivity: The terminal carboxylic acid is suitable for standard PROTAC assembly via amide coupling with amine-bearing ligands under activating conditions (for example, carbodiimide or uronium-type coupling reagents). Alternatively, it can be converted to activated esters for nucleophilic substitution. Reactions are typically performed in polar aprotic solvents with controlled pH to preserve PEG integrity and minimize side reactions.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂