mPEG2-hydrazide
CAS No.: 1442104-10-0
Cat No.: BP-501707
Purity: >98%
4.5 
mPEG2-hydrazide is a short, methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal hydrazide functional group, providing a flexible hydrophilic spacer for PROTAC and targeted protein degradation constructs. Structurally, it combines an ether-rich PEG chain that improves aqueous solubility and reduces nonspecific hydrophobic interactions with a hydrazide handle that can be used for chemoselective conjugation strategies, including formation of hydrazone linkages with carbonyl-bearing partners or coupling to activated carboxylates/activated derivatives depending on the synthetic route. In PROTAC design, this linker can be positioned to tune the effective distance and relative orientation between the ligand moieties, thereby influencing ternary complex formation and degradation potency while maintaining favorable pharmacokinetic-like physicochemical properties at the construct level. Its utility in targeted degradation research lies in enabling modular assembly, facilitating purification-friendly intermediates, and supporting systematic linker optimization to balance solubility, stability, and productive engagement of the recruited target and E3 ligase components.
Structure of 1442104-10-0
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mPEG2-hydrazide is an mPEG-based hydrazide linker designed for modular conjugation in targeted protein degradation workflows, including PROTAC assembly and related bioconjugation strategies. Its hydrazide functionality enables reliable coupling to carbonyl-containing partners, while the polyethylene glycol segment supports improved solubility and handling of linker–payload constructs. The following sections describe the structure and practical reactivity considerations for constructing PROTACs using this linker in a research setting.
Structure: The molecule comprises an mPEG chain terminating in a hydrazide group. It contains an amide-linked hydrazide motif with N–N and C–N connectivity, providing hydrogen-bonding capacity and chemical stability under typical aqueous organic coupling conditions. The PEG segment confers hydrophilicity and flexible conformational behavior.
Reactivity: Hydrazide linkers commonly participate in carbonyl-directed coupling, including formation of hydrazone linkages with aldehydes or ketones under mildly acidic conditions, followed by stabilization as required by the target construct design. For PROTAC synthesis, carbonyl partners are typically reacted in buffered aqueous/organic mixtures, with acid catalysts such as weak organic acids or controlled pH adjustments to promote condensation. Careful control of solvent composition and temperature helps manage hydrolysis and side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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