mPEG8-azide
CAS No.: 869718-80-9
Cat No.: BP-501128
Purity: >97%
4.5 
mPEG8-azide is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal azide functional group, providing a defined, short PEG chain that enhances solubility and biocompatible presentation while retaining a reactive handle for conjugation. In PROTAC and targeted degradation workflows, the azide enables bioorthogonal “click” chemistry (most commonly copper-catalyzed or strain-promoted azide–alkyne cycloaddition) to connect the PEGylated linker to complementary partners such as alkyne-bearing ligands or other PROTAC modules. This modular attachment strategy allows researchers to tune linker length and hydrophilicity, which can influence the effective spatial positioning of the recruiting moiety and the target-binding ligand, thereby affecting ternary complex formation and degradation efficiency. As a versatile PEG–azide building block, mPEG8-azide is valuable for constructing soluble, experimentally tractable PROTAC conjugates and for optimizing linker architecture during structure–activity relationship studies.
Structure of 869718-80-9
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mPEG8-azide is a polyethylene glycol (PEG)-based azide linker designed to enable efficient bioconjugation in targeted protein degradation workflows, including PROTAC assembly. Its hydrophilic PEG segment improves solubility and can help modulate the local microenvironment around the binding motifs, while the terminal azide provides a versatile handle for click-type coupling. The subsequent points describe the linker’s structure and practical reactivity considerations for researchers.
Structure: mPEG8-azide consists of an mPEG chain capped with a terminal azide functional group. The linker contains ether linkages along the PEG backbone and a stable organic azide at the terminus, providing a flexible, water-compatible scaffold suitable for conjugation chemistry.
Reactivity: The terminal azide enables copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, allowing attachment to complementary alkyne-bearing PROTAC fragments. Typical conditions use an appropriate Cu(I) source with stabilizing ligands in polar solvents for CuAAC, or catalyst-free SPAAC with cyclooctyne/related strained alkynes. Reaction efficiency depends on solvent polarity, oxygen sensitivity for CuAAC, and maintaining azide integrity during handling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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