Name: Ms-PEG8-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-methylsulfonyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

InChI Key

ARFPSYCSFDJABG-UHFFFAOYSA-N

InChI

InChI=1S/C24H48O13S/c1-24(2,3)37-23(25)5-6-28-7-8-29-9-10-30-11-12-31-13-14-32-15-16-33-17-18-34-19-20-35-21-22-36-38(4,26)27/h5-22H2,1-4H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)C

This heterofunctional oligoether linker precursor combines a mesylate electrophile with an acid-labile protected carboxyl group. It enables nucleophilic attachment at one terminus and later amidation at the other, supporting directional assembly of flexible PROTAC linkers. Its properties are detailed below.

Structure: An extended oligoether chain terminates in a methanesulfonate and a tert-butyl propanoate. Numerous ether bonds provide conformational freedom, while the sulfonate ester supplies an electrophilic carbon bearing an effective leaving group and the ester masks a terminal carboxylic acid.

Reactivity: Displace the mesylate with an amine, thiolate, phenoxide, or azide through bimolecular nucleophilic substitution in anhydrous dimethylformamide, acetonitrile, or another polar aprotic solvent; a nonnucleophilic base may be used when appropriate. Acidic cleavage of the tert-butyl ester subsequently reveals a carboxyl group for carbodiimide- or uronium-mediated amidation with an amine-bearing PROTAC component.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂