N-(Amino-PEG3)-N-bis(PEG3-Boc)
CAS No.: 2055042-62-9
Cat No.: BP-500277
4.5 
N-(Amino-PEG3)-N-bis(PEG3-Boc) is a branched, protected PEG linker scaffold. Structurally, it contains a central tertiary amine bearing one amino-PEG3 arm and two PEG3 arms terminated with propionic acids protected as tert-butyl esters. The free primary amine can be coupled to activated acids or isocyanates, while acid-mediated deprotection of the two tert-butyl esters exposes two carboxylic acids for additional amide or ester formation. In PROTAC and related targeted protein degradation research, the three-arm architecture supports multivalent or branched conjugate construction and should not be described as containing two Boc-protected amines. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 2055042-62-9
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This amino-PEG3-based linker is designed to provide a flexible, hydrophilic spacer for assembling PROTAC constructs, supporting favorable solubility and productive ternary complex formation. Its PEG-rich architecture helps reduce nonspecific hydrophobic interactions and can improve handling during linker–ligand conjugation. The molecule’s protected amine functionality enables controlled coupling strategies, and the subsequent sections describe its structural and reactivity characteristics in detail below.
Structure: The linker contains an amino-terminated oligo(ethylene glycol) segment and additional PEG3 units bearing Boc-protected functionalities. It features ether linkages within the PEG chain, enabling conformational flexibility and strong hydrogen-bonding interactions. The presence of Boc groups provides chemical stability until deprotection is performed.
Reactivity: For PROTAC synthesis, Boc-protected amines are typically deprotected under acidic conditions to generate a reactive primary amine. Subsequent coupling to complementary electrophiles (for example, activated esters or suitably functionalized haloacetamides) proceeds via nucleophilic substitution or amide-bond formation. Common solvents include polar aprotic media, and coupling steps are often facilitated by standard peptide-coupling reagents or base/activator systems compatible with PEG linkers.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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