N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester - CAS 2112732-03-1

Inquiry

N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a polyethylene glycol (PEG)-based PROTAC linker. N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester can be used in the synthesis of a series of PROTACs.

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Molecular Formula

C₂₆H₅₀N₄O₁₀

Molecular Weight

578.70

N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester

- Specification
  - Purity
    
    98%
    
    Storage
    
    Please store the product under the recommended conditions in the Certificate of Analysis.
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    tert-butyl 3-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethoxy]ethoxy]ethoxy]propanoate
    
    Synonyms
    
    tert-butyl 3-(2-{2-[2-(16-azido-2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-5-yl)ethoxy]ethoxy}ethoxy)propanoate
- Properties
  - InChI Key
    
    IZIWQDDVTKZAPK-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C26H50N4O10/c1-25(2,3)39-23(31)7-11-33-15-19-37-21-17-35-13-9-30(24(32)40-26(4,5)6)10-14-36-18-22-38-20-16-34-12-8-28-29-27/h7-22H2,1-6H3
    
    Canonical SMILES
    
    CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C
- Reference Reading
  - 1. Notch Signaling Mediates Radiation-Induced Smooth Muscle Cell Hypermuscularization and Cerebral Vasculopathy
    
    Yuhua Yang, Honghong Li, Yongteng Xu, Jiatian Xie, Qiang Liu, Zhongshan Shi, Jialin Huang, Jinping Cheng, Siqi Chen, Sitai Chen, Xiaohui Zhao, Shaojian Li, Zhan Zhang, Jinhua Cai, Baixuan He, Wei-Jye Lin, Qingyu Shen, Yi Li, Yamei Tang Stroke. 2022 Dec;53(12):3751-3762.doi: 10.1161/STROKEAHA.122.040697.Epub 2022 Oct 28.
    
    Background:Emerging evidence highlighted vascular injury in aggravating radiation-induced brain injury (RIBI), a common complication of radiotherapy. This study aimed to delineate the pathological feature of cerebral small vessel and investigate the functional roles of Notch signaling in RIBI.

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It is commonly abbreviated as: C₁V₁ = C₂V₂

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳

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