Pentaethylene glycol di(p-toluenesulfonate)
CAS No.: 41024-91-3
Cat No.: BP-500830
Purity: ≥95%
4.5 
Pentaethylene glycol di(p-toluenesulfonate) is a bifunctional PEG-based linker in which a pentaethylene glycol spacer is terminated with two tosylate leaving groups, enabling efficient nucleophilic substitution to install PROTAC “handles” on either end. Structurally, it provides a flexible, hydrophilic chain length that can reduce steric bias and help position two ligands or functional moieties for productive ternary complex formation. In PROTAC design, this type of di-activated linker is commonly used to conjugate amine- or phenol-containing warheads, allowing formation of a stable ether or amide linkage while the tosylate groups serve as reactive intermediates during synthesis. Its value for targeted protein degradation research lies in offering a modular, convergent route to generate linker-bridged degraders with tunable geometry and improved solubility, facilitating systematic structure–activity relationship studies and optimization of degradation potency and selectivity.
Structure of 41024-91-3
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This pentaethylene glycol di(p-toluenesulfonate) linker is a bifunctional, polyethylene glycol–based sulfonate building block designed for assembling PROTACs through efficient nucleophile-driven substitutions. Its flexible ether-rich scaffold supports productive spatial positioning between ligands, while the activated tosylate termini enable modular conjugation under standard organic synthesis conditions. The subsequent points describe its structural features and practical reactivity considerations for PROTAC linker integration.
Structure: The molecule contains a central pentaethylene glycol chain with two terminal p-toluenesulfonate (tosylate) leaving groups. It features multiple ether linkages providing conformational flexibility, aromatic sulfonate substituents, and sulfonate ester functionality. Overall, it is an activated di-electrophile suitable for stepwise PROTAC assembly.
Reactivity: Tosylate groups undergo nucleophilic substitution with appropriate amines, thiols, or oxygen nucleophiles to form stable C–N, C–S, or C–O linkages. PROTAC construction typically employs base-mediated generation of the nucleophile, followed by reaction in polar aprotic or suitable organic solvents to promote substitution. Reaction efficiency depends on nucleophile strength and steric accessibility, with mild conditions commonly used to preserve sensitive ligand chemistries.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
