Tri(Amino-PEG4-amide)-amine
Cat No.: BP-501725
4.5 
Tri(Amino-PEG4-amide)-amine is a branched, tri-functional polyethylene glycol (PEG)-based linker featuring three terminal amine groups connected through PEG4 segments to amide linkages, providing a flexible, hydrophilic scaffold for bioconjugation. In PROTAC construction, such multi-arm linkers are used to spatially organize and tune the effective distance and relative orientation between the two binding modules (e.g., an E3 ligase ligand and a target-binding ligand), while the PEG chains help reduce nonspecific hydrophobic interactions and improve aqueous solubility. The amide-linked PEG arms can be exploited for controlled coupling chemistries to attach payloads or ligands via amide-forming or amine-reactive steps, enabling systematic variation of linker length and branching to modulate ternary complex formation and degradation potency. This linker is therefore valuable for researchers optimizing targeted protein degradation systems, particularly when multivalent or sterically balanced architectures are required to achieve robust cellular activity.
-amine.gif)
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.1260 mL | 5.6300 mL | 11.2600 mL |
| 5 mM | 0.2252 mL | 1.1260 mL | 2.2520 mL |
| 10 mM | 0.1126 mL | 0.5630 mL | 1.1260 mL |
Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based, multi-functional linker designed to support PROTAC assembly by providing flexible spacing and multiple reactive handles for conjugation. Its amide-linked PEG architecture can help tune linker length, solvation, and accessibility of the binding partners, which are critical for efficient ternary complex formation and targeted protein degradation. The points below describe the structure and practical reactivity considerations for constructing PROTACs using this linker.
Structure: The linker comprises a tri-functional amine scaffold substituted with PEG chains terminated by amide linkages, creating a flexible, hydrophilic framework. It contains primary amines and amide bonds, with ether oxygen atoms contributing to strong hydrogen-bonding capacity and water compatibility. This combination supports conformational mobility in bioconjugation workflows.
Reactivity: PROTAC synthesis using this linker typically relies on amine-directed coupling strategies, including amide-bond formation via activated carboxylic acids or carbodiimide-mediated chemistry, and reductive amination when appropriate carbonyl partners are used. Reaction conditions are commonly optimized for aqueous/organic compatibility to preserve PEG solubility and minimize hydrolysis of activated intermediates. Base catalysts and coupling reagents are selected to favor selective attachment while maintaining amine integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
