Propargyl-PEG4-S-PEG4-propargyl
CAS No.: 2055041-17-1
Cat No.: BP-501241
Purity: 98%
4.5 
Propargyl-PEG4-S-PEG4-propargyl is a symmetric homobifunctional, PEG-based dialkyne linker featuring two terminal propargyl (alkyne) groups connected through two short tetra(ethylene glycol) segments that are joined by a thioether (S) linkage. The flexible PEG chains provide aqueous solubility and conformational freedom, while the thioether offers a stable, non-amide connection point that can be positioned to tune the effective distance and relative orientation between the two conjugated partners. In PROTAC design, this linker is used to couple azide-bearing partners at either end via the same CuAAC chemistry, enabling efficient formation of triazole-linked conjugates under mild conditions. Its polyethylene glycol spacers help reduce steric clashes and can improve the productive geometry required for ternary complex formation, thereby supporting systematic optimization of degrader potency and selectivity in targeted protein degradation research.
Structure of 2055041-17-1
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This Propargyl-PEG4-S-PEG4-propargyl linker is designed for modular PROTAC assembly, providing two terminal propargyl handles for orthogonal conjugation and a flexible polyethylene glycol scaffold that can improve solubility and spatial reach between binding modules. The central thioether linkage offers a defined connectivity point while maintaining conformational flexibility. Detailed structural and synthetic considerations for constructing PROTACs with this linker are provided below.
Structure: The linker contains a flexible PEG-based polyether backbone flanked by propargyl groups, enabling alkyne-functional chemistry at both ends. A central thioether (S-linked) connection provides a stable sulfur-containing linkage. Overall, it presents ether-rich, polar segments that support aqueous compatibility and conformational adaptability.
Reactivity: The terminal propargyl groups are suitable for alkyne-involved coupling strategies commonly used in PROTAC synthesis, including copper-catalyzed azide–alkyne cycloaddition and related click-type conjugations. Typical approaches rely on mild conditions that preserve sensitive ligands, using appropriate copper sources, stabilizing ligands, and polar solvents compatible with both partners. Mechanistically, the alkyne participates in selective bond formation to connect targeting and E3-recruiting components through robust triazole or analogous linkages.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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