SPDP-PEG4-COOH

 CAS No.: 581065-97-6  Cat No.: BP-501510  Purity: ≥95% 4.5  

SPDP-PEG4-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.

SPDP-PEG4-COOH

Structure of 581065-97-6

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Category
PROTAC Linker
Molecular Formula
C19H30N2O7S2
Molecular Weight
462.58
Appearance
Yellow Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Yellow Oily Matter
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
SPDP-PEG4-acid; 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid; OPSS-PEG4-COOH; N-[3-(o-Pyridyldisulfido)propanoyl]-15-amino-4,7,10,13-tetraoxa-pentadecanoic acid; OPSS-PEG4-COOH
Boiling Point
677.3±55.0 °C at 760 mmHg
Density
1.3±0.1 g/cm3
InChI Key
IJDPYTZOKIVWAN-UHFFFAOYSA-N
InChI
InChI=1S/C19H30N2O7S2/c22-17(5-16-29-30-18-3-1-2-6-21-18)20-7-9-26-11-13-28-15-14-27-12-10-25-8-4-19(23)24/h1-3,6H,4-5,7-16H2,(H,20,22)(H,23,24)
Canonical SMILES
C1=CC=NC(=C1)SSCCC(=O)NCCOCCOCCOCCOCCC(=O)O

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
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Historical Records: Boc-PEG2-sulfonic acid | Hydroxy-PEG16-acid | Boc-NH-PEG3-sulfonic acid | Azido-PEG12-alcohol | S-acetyl-PEG12-alcohol | Bis-PEG10-acid | N-(Amino-PEG5)-N-bis(PEG4-acid) | BCN-PEG4-alkyne | TCO-PEG3-acid | SPDP-PEG4-COOH

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