t-Boc-Aminooxy-PEG7-bromide
CAS No.: 2353410-15-6
Cat No.: BP-500385
4.5 
t-Boc-Aminooxy-PEG7-bromide is a functionalized polyethylene glycol (PEG) linker bearing a terminal bromide for alkylation and a protected aminooxy group for subsequent oxime-based conjugation. Structurally, it combines a Boc-protected aminooxy handle with a seven-unit PEG chain, providing a hydrophilic, flexible spacer that can reduce steric hindrance and improve solubility in PROTAC assemblies. In targeted protein degradation workflows, the aminooxy functionality enables formation of oxime linkages with carbonyl-bearing partners (e.g., aldehyde or ketone groups introduced on ligands), while the bromide can be used to install the linker onto nucleophilic sites or to generate reactive intermediates for controlled attachment. This dual-reactivity makes the reagent valuable for constructing modular PROTACs and related bifunctional degraders, where precise linker length, attachment chemistry, and aqueous compatibility are critical for maintaining ternary complex formation and degradation potency.
Structure of 2353410-15-6
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t-Boc-Aminooxy-PEG7-bromide is a PEG-based, bromide-terminated linker designed for modular synthesis of PROTACs and other targeted protein degradation constructs. Its aminooxy functionality supports formation of stable oxime linkages with carbonyl-bearing ligands, while the PEG spacer helps tune solubility and the effective distance between binding and recruitment elements. The bromide handle enables efficient attachment chemistry, facilitating streamlined assembly of degradation scaffolds; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a poly(ethylene glycol) chain terminated by a bromide and bearing a protected aminooxy group. It contains ether linkages within the PEG segment, an aminooxy moiety masked as a Boc carbamate, and a carbon–oxygen and carbon–nitrogen connectivity pattern suitable for bond-forming steps in PROTAC synthesis.
Reactivity: For PROTAC construction, the Boc group is typically removed under standard acid-mediated deprotection to reveal the free aminooxy functionality, which can then react with aldehyde or ketone groups to form oxime linkages. The bromide terminus can participate in nucleophilic substitution or related coupling strategies to install the linker onto electrophilic partners. Common conditions use polar aprotic solvents and base or acid systems compatible with PEG stability and oxime formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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