TCO-PEG36-acid
Cat No.: BP-501742
Purity: 95%
4.5 
TCO-PEG36-acid is a polyethylene glycol (PEG) linker bearing a trans-cyclooctene (TCO) moiety and a terminal carboxylic acid. Structurally, it provides a long, flexible hydrophilic chain that spatially separates two conjugation partners while maintaining the TCO group in a reactive, strained-alkene form suitable for fast bioorthogonal ligation. In PROTAC and targeted degradation workflows, the TCO handle is commonly used to enable chemoselective coupling to tetrazine-functionalized counterparts via inverse-electron-demand Diels–Alder chemistry, thereby generating a stable, covalent connection between the ligand-derived warhead and the E3-recruiting or scaffold component. The terminal acid additionally supports downstream derivatization or amide/ester formation for controlled attachment to other chemical units. This linker is valuable for optimizing linker length and flexibility to balance ternary complex formation, degradation potency, and physicochemical properties in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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TCO-PEG36-acid is a polyethylene glycol-based PROTAC linker designed to connect targeting and recruiting modules while improving solubility, conformational flexibility, and effective spatial presentation in targeted protein degradation workflows. Its acid functionality enables reliable conjugation strategies commonly used in PROTAC assembly, supporting robust linker integration without disrupting key binding pharmacophores. The detailed structural and synthetic considerations are provided below for researchers planning linker-to-warhead coupling and subsequent PROTAC construction.
Structure: This linker comprises a PEG oligomer chain terminating in a carboxylic acid, providing a flexible, hydrophilic scaffold. The structure features ether linkages along the PEG backbone and a terminal carboxyl group for acid-mediated coupling. Such architectures are typically compatible with aqueous handling and minimize aggregation.
Reactivity: The carboxylic acid group is suitable for amide-bond formation with amine-bearing PROTAC components using standard coupling chemistries. Common approaches employ carbodiimide-type activators with additives to suppress side reactions, typically in polar aprotic solvents or buffered media depending on substrate stability. The mechanism involves acid activation followed by nucleophilic attack to form a stable amide linkage, enabling modular assembly of PROTAC constructs under mild, experimentally controllable conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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