THP-PEG16-THP
Cat No.: BP-501991
4.5 
THP-PEG16-THP is a homobifunctional polyethylene glycol (PEG) linker featuring two tetrahydropyranyl (THP) ether termini connected through a PEG chain of intermediate length, providing a flexible, hydrophilic spacer between PROTAC-relevant attachment points. In PROTAC architectures, such PEG linkers are commonly used to tune the effective distance and relative orientation between the ligand-binding domains, improving productive formation of the ternary complex and reducing steric clashes that can limit targeted protein degradation. The THP end groups serve as chemically addressable capping/functional handles that can be converted or engaged during linker installation or subsequent synthetic steps, enabling controlled conjugation to warhead and E3-ligase ligand scaffolds. This product is valuable for researchers optimizing linker length and polarity in targeted degradation programs, as PEG-based spacers often enhance solubility and can modulate intracellular behavior, thereby supporting systematic structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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THP-PEG16-THP is a polyethylene glycol-based linker designed to connect two THP (tetrahydropyran) functional termini for use in targeted protein degradation workflows. Its flexible PEG architecture supports productive ternary complex formation, while the THP-derived handles enable controlled conjugation strategies to assemble PROTACs. This linker is particularly useful when linker length, conformational adaptability, and synthetic modularity are critical. Detailed structural and reaction considerations are provided below.
Structure: THP-PEG16-THP contains a central PEG chain flanked by THP-protected tetrahydropyran motifs. The linker features ether-rich connectivity with flexible C–O and C–C frameworks, providing conformational mobility and hydrophilicity. Such PEG/THP architectures typically enhance solubility and reduce aggregation tendencies in linker–ligand conjugates.
Reactivity: THP termini are commonly handled via protecting-group chemistry, enabling installation of PROTAC-compatible connection points through activation and subsequent coupling. Linker assembly is typically performed under conditions that preserve the PEG ether backbone while selectively transforming THP-derived functionalities. Reaction planning should consider orthogonality with the warhead and E3 ligase ligand chemistries, using standard coupling or substitution approaches with appropriate bases, dry polar solvents, and inert atmosphere when required for sensitive intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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