Tos-PEG4-O-CH2COOH

 CAS No.: 2028284-73-1  Cat No.: BP-500818  Purity: ≥95% 4.5  

Tos-PEG4-O-CH2COOH is a PEG linker containing a tosyl group and a terminal carboxylic acid. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Tos-PEG4-O-CH2COOH

Structure of 2028284-73-1

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Category
PROTAC Linker
Molecular Formula
C17H26O9S
Molecular Weight
406.45
Appearance
Pale Yellow Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Pale Yellow Oily Matter
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Synonyms
14-(Tosyloxy)-3,6,9,12-tetraoxatetradecanoic acid; Tos-PEG5-CH2CO2H; Tos-PEG5-CH2COOH; Tos-PEG4-CH2COOH; Acetic acid, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-; 14-{[(4-Methylphenyl)sulfonyl]oxy}-3,6,9,12-tetraoxatetradecan-1-oic acid; 3,6,9,12-Tetraoxatetradecan-1-oic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-
Boiling Point
567.7±50.0°C (Predicted)
Density
1.260±0.06 g/cm3 (Predicted)
InChI Key
MTBIBZOLTXFDIU-UHFFFAOYSA-N
InChI
InChI=1S/C17H26O9S/c1-15-2-4-16(5-3-15)27(20,21)26-13-12-24-9-8-22-6-7-23-10-11-25-14-17(18)19/h2-5H,6-14H2,1H3,(H,18,19)
Canonical SMILES
CC1=CC=C(S(=O)(OCCOCCOCCOCCOCC(O)=O)=O)C=C1

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: NH-bis(PEG2-propargyl) | Benzyl-PEG6-NHBoc | m-PEG2-amido-Ph-NH2 | Boc-PEG4-methyl propionate | Propargyl-PEG4-CH2-acid | Hydroxy-PEG5-t-butyl acetate | Propargyl-PEG5-NHBoc | 1,2-Bis(2-propynyloxy)ethane | Azido-PEG5-alcohol | Amino-PEG2-C2-hydrazide-Boc | Tos-PEG4-O-CH2COOH

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