Name: Tos-PEG7-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Synonyms

tert-butyl 1-(tosyloxy)-3,6,9,12,15,18-hexaoxahenicosan-21-oate; Tos-peg7-t-butyl ester; Tos-PEG7-t-Butyl ester; Tos-PEG7-Boc

Boiling Point

621.1±55.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

HMGVIAOGIVRIFP-UHFFFAOYSA-N

InChI

InChI=1S/C26H44O11S/c1-23-5-7-24(8-6-23)38(28,29)36-22-21-35-20-19-34-18-17-33-16-15-32-14-13-31-12-11-30-10-9-25(27)37-26(2,3)4/h5-8H,9-22H2,1-4H3

SMILES

CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C

Tos-PEG7-COOtBu is a PEG-based PROTAC linker building block designed to connect targeting ligands and enable efficient formation of ternary complexes through controlled spatial separation and improved solubility. Its ether-rich polymer segment supports aqueous compatibility, while the protected carboxyl functionality provides a reliable handle for subsequent conjugation steps. This product is commonly used in targeted protein degradation workflows, where linker architecture strongly influences degrader geometry, flexibility, and overall performance. Detailed structural and reactivity considerations are provided below.

Structure: The linker contains a tosyl-activated PEG chain featuring multiple ether linkages that impart conformational flexibility. A terminal protected carboxyl group is present as a tert-butyl ester, which stabilizes the acid functionality during synthetic assembly. Aromatic sulfonate character supports leaving-group behavior in downstream transformations.

Reactivity: Tosyl activation enables nucleophilic substitution reactions under standard organic synthesis conditions, typically using appropriate nucleophiles such as amines or carboxylates to form new C–N or C–O bonds. The tert-butyl ester is compatible with many coupling steps and can be deprotected using acid-mediated conditions to reveal the free carboxylic acid for amide bond formation. Common solvents include polar aprotic media, and coupling can proceed via established carboxyl activation strategies.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂