PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202473	2-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide		CRBN	FLT3 FLT3-ITD FLT3-ITD-D835V FLT3-ITD-F691L	Inquiry
Molecular Weight: 827.91 Molecular Formula: C42H45N13O6 Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
	BPL-202474	(1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-N-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxamide	2758029-56-8	CRBN	MDM2	Inquiry
Molecular Weight: 843.12 Molecular Formula: C49H70N4O8 Boiling Point: 949.7±65.0°C at 760 Torr Density: 1.25±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202475	(1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-N-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxamide	2758029-58-0	CRBN	MDM2	Inquiry
Molecular Weight: 887.17 Molecular Formula: C51H74N4O9 Boiling Point: 968.8±65.0°C at 760 Torr Density: 1.24±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202476	(1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-N-(14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxamide	2758029-60-4	CRBN	MDM2	Inquiry
Molecular Weight: 931.23 Molecular Formula: C53H78N4O10 Boiling Point: 987.8±65.0°C at 760 Torr Density: 1.24±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202477	1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-12-oxo-3,6,9,13-tetraoxapentadecan-15-yl (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate	2758029-62-6	CRBN	MDM2	Inquiry
Molecular Weight: 960.22 Molecular Formula: C54H77N3O12 Boiling Point: 962.4±65.0°C at 760 Torr Density: 1.26±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202478	2-((3-(2-(2-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)propanoyl)oxy)ethyl (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate	2758029-64-8	CRBN	MDM2	Inquiry
Molecular Weight: 997.24 Molecular Formula: C55H76N6O11 Density: 1.37±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202479	(1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-N-(8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxamide	2758029-66-0	CRBN	MDM2	Inquiry
Molecular Weight: 839.18 Molecular Formula: C51H74N4O6 Boiling Point: 947.0±65.0°C at 760 Torr Density: 1.20±0.1 g/cm3 Description: It is a ursane-thalidomide-based PROTAC that targets the degradation of MDM2 protein.
	BPL-202480	4-((4-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)butyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-02-2	CRBN	PD-L1	Inquiry
Molecular Weight: 690.80 Molecular Formula: C40H42N4O7 Boiling Point: 884.0±65.0°C at 760 Torr Density: 1.276±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202481	4-((5-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)pentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-04-4	CRBN	PD-L1	Inquiry
Molecular Weight: 704.82 Molecular Formula: C41H44N4O7 Boiling Point: 889.4±65.0°C at 760 Torr Density: 1.264±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202482	4-((6-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)hexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-08-8	CRBN	PD-L1	Inquiry
Molecular Weight: 718.85 Molecular Formula: C42H46N4O7 Boiling Point: 894.9±65.0°C at 760 Torr Density: 1.252±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202483	4-((7-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-10-2	CRBN	PD-L1	Inquiry
Molecular Weight: 732.88 Molecular Formula: C43H48N4O7 Boiling Point: 900.6±65.0°C at 760 Torr Density: 1.241±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202484	4-((8-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)octyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-14-6	CRBN	PD-L1	Inquiry
Molecular Weight: 746.91 Molecular Formula: C44H50N4O7 Boiling Point: 906.4±65.0°C at 760 Torr Density: 1.230±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202485	4-((9-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)nonyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2674083-15-7	CRBN	PD-L1	Inquiry
Molecular Weight: 760.93 Molecular Formula: C45H52N4O7 Boiling Point: 900.5±65.0°C at 760 Torr Density: 1.220±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202486	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-5-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pent-4-ynamide	2674083-17-9	CRBN	PD-L1	Inquiry
Molecular Weight: 742.83 Molecular Formula: C43H42N4O8 Boiling Point: 967.8±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202487	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)hex-5-ynamide	2674083-18-0	CRBN	PD-L1	Inquiry
Molecular Weight: 756.86 Molecular Formula: C44H44N4O8 Boiling Point: 975.3±65.0°C at 760 Torr Density: 1.34±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202488	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)hept-6-ynamide	2674083-22-6	CRBN	PD-L1	Inquiry
Molecular Weight: 770.88 Molecular Formula: C45H46N4O8 Boiling Point: 980.6±65.0°C at 760 Torr Density: 1.32±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202489	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-5-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pent-4-ynamide	2674083-24-8	CRBN	PD-L1	Inquiry
Molecular Weight: 742.83 Molecular Formula: C43H42N4O8 Boiling Point: 965.3±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202490	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hex-5-ynamide	2674083-25-9	CRBN	PD-L1	Inquiry
Molecular Weight: 756.86 Molecular Formula: C44H44N4O8 Boiling Point: 972.8±65.0°C at 760 Torr Density: 1.34±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202491	N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hept-6-ynamide	2674083-28-2	CRBN	PD-L1	Inquiry
Molecular Weight: 770.88 Molecular Formula: C45H46N4O8 Boiling Point: 978.2±65.0°C at 760 Torr Density: 1.32±0.1 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.
	BPL-202492	2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethyl)acetamide	2674083-41-9	CRBN	PD-L1	Inquiry
Molecular Weight: 777.83 Molecular Formula: C42H43N5O10 Boiling Point: 1039.4±65.0°C at 760 Torr Density: 1.317±0.06 g/cm3 Description: It is a proteolysis targeting chimera (PROTAC) that degrades programmed cell death ligand 1 (PD-L1) in vitro and in vivo.