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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(2R,4S)-1-((S)-18-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,16-dioxo-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202453 (2R,4S)-1-((S)-18-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,16-dioxo-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-80-9

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1250.37

Molecular Formula: C60H65F2N11O13S2

Density: 1.44±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-21-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,19-dioxo-5,8,11,14,17-pentaoxa-2,20-diazadocosan-22-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202454 (2R,4S)-1-((S)-21-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,19-dioxo-5,8,11,14,17-pentaoxa-2,20-diazadocosan-22-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-81-0

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1294.43

Molecular Formula: C62H69F2N11O14S2

Density: 1.42±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-24-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,22-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazapentacosan-25-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202455 (2R,4S)-1-((S)-24-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,22-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazapentacosan-25-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-82-1

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1338.48

Molecular Formula: C64H73F2N11O15S2

Density: 1.41±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
3-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202456 3-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 785.83

Molecular Formula: C39H39N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
4-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide BPL-202457 4-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 799.85

Molecular Formula: C40H41N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
5-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide BPL-202458 5-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 813.88

Molecular Formula: C41H43N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
6-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide BPL-202459 6-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 827.91

Molecular Formula: C42H45N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
2-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide BPL-202460 2-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 771.80

Molecular Formula: C38H37N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
2-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202461 2-(4-((4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 785.83

Molecular Formula: C39H39N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
3-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202462 3-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 813.88

Molecular Formula: C41H43N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
4-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide BPL-202463 4-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 827.91

Molecular Formula: C42H45N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
5-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide BPL-202464 5-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 841.93

Molecular Formula: C43H47N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
6-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide BPL-202465 6-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 855.96

Molecular Formula: C44H49N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
2-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide BPL-202466 2-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 799.85

Molecular Formula: C40H41N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
2-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202467 2-(4-(3-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 813.88

Molecular Formula: C41H43N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
3-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-202468 3-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 827.91

Molecular Formula: C42H45N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
4-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide BPL-202469 4-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)butanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 841.93

Molecular Formula: C43H47N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
5-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide BPL-202470 5-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 855.96

Molecular Formula: C44H49N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
6-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide BPL-202471 6-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 869.99

Molecular Formula: C45H51N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.
2-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide BPL-202472 2-(4-(4-(4-Amino-5-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)butyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide

CRBN

FLT3
FLT3-ITD
FLT3-ITD-D835V
FLT3-ITD-F691L

 Inquiry

Molecular Weight: 813.88

Molecular Formula: C41H43N13O6

Description: It is a proteolysis targeting chimera (PROTAC) that degrades FLT3-ITD protein.

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