PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202373	Ethyl 3-(2-(tert-butylamino)-1-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-83-5	CRBN	MDM2	Inquiry
Molecular Weight: 866.29 Molecular Formula: C46H39ClF3N5O7 Boiling Point: 1082.2±65.0°C at 760 Torr Density: 1.47±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202374	Ethyl 3-(2-(tert-butylamino)-1-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-84-6	CRBN	MDM2	Inquiry
Molecular Weight: 866.29 Molecular Formula: C46H39ClF3N5O7 Boiling Point: 1082.2±65.0°C at 760 Torr Density: 1.47±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202375	Ethyl 3-(2-(tert-butylamino)-1-(3-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-85-7	CRBN	MDM2	Inquiry
Molecular Weight: 937.37 Molecular Formula: C49H44ClF3N6O8 Boiling Point: 1169.4±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202376	Ethyl 3-(2-(tert-butylamino)-1-(3-(6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-86-8	CRBN	MDM2	Inquiry
Molecular Weight: 951.40 Molecular Formula: C50H46ClF3N6O8 Boiling Point: 1171.1±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202377	Ethyl 3-(2-(tert-butylamino)-1-(3-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-87-9	CRBN	MDM2	Inquiry
Molecular Weight: 965.43 Molecular Formula: C51H48ClF3N6O8 Boiling Point: 1173.0±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202378	Ethyl 3-(2-(tert-butylamino)-1-(4-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-88-0	CRBN	MDM2	Inquiry
Molecular Weight: 937.37 Molecular Formula: C49H44ClF3N6O8 Boiling Point: 1169.4±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202379	Ethyl 3-(2-(tert-butylamino)-1-(4-(6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-89-1	CRBN	MDM2	Inquiry
Molecular Weight: 951.40 Molecular Formula: C50H46ClF3N6O8 Boiling Point: 1171.1±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202380	Ethyl 3-(2-(tert-butylamino)-1-(4-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynamido)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-90-4	CRBN	MDM2	Inquiry
Molecular Weight: 965.43 Molecular Formula: C51H48ClF3N6O8 Boiling Point: 1173.0±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202381	Ethyl 3-(2-(tert-butylamino)-1-(3-((3-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)prop-2-yn-1-yl)oxy)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-91-5	CRBN	MDM2	Inquiry
Molecular Weight: 896.32 Molecular Formula: C47H41ClF3N5O8 Boiling Point: 1098.1±65.0°C at 760 Torr Density: 1.47±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202382	Ethyl 3-(2-(tert-butylamino)-1-(3-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)but-3-yn-1-yl)oxy)-N-(3,4,5-trifluorobenzyl)benzamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-92-6	CRBN	MDM2	Inquiry
Molecular Weight: 910.35 Molecular Formula: C48H43ClF3N5O8 Boiling Point: 1100.7±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202383	Ethyl 3-(2-(tert-butylamino)-1-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-ethylhept-6-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-93-7	CRBN	MDM2	Inquiry
Molecular Weight: 730.26 Molecular Formula: C39H44ClN5O7 Boiling Point: 991.7±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202384	N-(2-(tert-Butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-ethylhept-6-ynamide	2640723-94-8	CRBN	MDM2	Inquiry
Molecular Weight: 619.16 Molecular Formula: C34H39ClN4O5 Boiling Point: 881.8±65.0°C at 760 Torr Density: 1.30±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202385	N-(2-(tert-Butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamide	2640723-95-9	CRBN	MDM2	Inquiry
Molecular Weight: 735.20 Molecular Formula: C39H38ClF3N4O5 Boiling Point: 938.9±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202386	N-(1-(tert-Butylamino)-3-methyl-1-oxobutan-2-yl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamide	2640723-96-0	CRBN	MDM2	Inquiry
Molecular Weight: 666.74 Molecular Formula: C36H41F3N4O5 Boiling Point: 873.4±65.0°C at 760 Torr Density: 1.30±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202387	N-(2-(tert-Butylamino)-1-cyclohexyl-2-oxoethyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamide	2640723-97-1	CRBN	MDM2	Inquiry
Molecular Weight: 706.81 Molecular Formula: C39H45F3N4O5 Boiling Point: 909.8±65.0°C at 760 Torr Density: 1.30±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202388	Ethyl 6-chloro-3-((7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamido)methyl)-1H-indole-2-carboxylate	2640723-98-2	CRBN	MDM2	Inquiry
Molecular Weight: 747.17 Molecular Formula: C39H34ClF3N4O6 Boiling Point: 958.4±65.0°C at 760 Torr Density: 1.47±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202389	N-(4-Chlorobenzyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamide	2640723-99-3	CRBN	MDM2	Inquiry
Molecular Weight: 636.07 Molecular Formula: C34H29ClF3N3O4 Boiling Point: 844.9±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202390	YF135		VHL	KRAS G12C	Inquiry
Molecular Weight: 1179.89 Molecular Formula: C63H75ClN12O7S Density: 1.3±0.1 g/cm3 Description: YF135 is the first reversible-covalent PROTAC capable of recruiting VHL mediated proteasomal degradation of KRASG12C. YF135 induces the rapid and sustained degradation of endogenous KRASG12C and attenuates pERK signaling in H358 and H23 cells in a reversible manner.
	BPL-202391	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide	2653335-21-6	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 721.13 Molecular Formula: C36H29ClN8O7 Density: 1.534±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202392	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)acetamide	2653335-22-7	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 749.18 Molecular Formula: C38H33ClN8O7 Density: 1.489±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.