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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202433 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

VHL

FAK

 Inquiry

Molecular Weight: 1029.20

Molecular Formula: C52H63F3N10O7S

Description: It is a highly cooperative FAK-degrading PROTAC.
(2S,4R)-4-Hydroxy-1-((S)-2-(3-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)propanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202434 (2S,4R)-4-Hydroxy-1-((S)-2-(3-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)propanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

VHL

FAK

 Inquiry

Molecular Weight: 999.17

Molecular Formula: C51H61F3N10O6S

Description: It is a highly cooperative FAK-degrading PROTAC.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide BPL-202435 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 866.36

Molecular Formula: C41H40ClN11O7S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide BPL-202436 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 865.38

Molecular Formula: C41H41ClN12O6S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide BPL-202437 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 797.34

Molecular Formula: C39H41ClN10O5S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((4-(2,6-dioxopiperidin-3-yl)phenyl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide BPL-202438 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((4-(2,6-dioxopiperidin-3-yl)phenyl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 796.36

Molecular Formula: C39H42ClN11O4S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)acetamide BPL-202439 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 716.26

Molecular Formula: C36H38ClN7O5S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
SJ995973 BPL-202440 SJ995973

CRBN

BRD4
BRD2

 Inquiry

Molecular Weight: 730.29

Molecular Formula: C37H40ClN7O5S

Density: 1.4±0.1 g/cm3

Description: SJ995973 is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins that inhibits the viability of human acute myeloid leukemia MV4-11 cells at low picomolar concentrations (IC50=3 pM; BRD4 DC50=0.87 nM).
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)acetamide BPL-202441 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)butyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 716.26

Molecular Formula: C36H38ClN7O5S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(5-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)pentyl)acetamide BPL-202442 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(5-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)pentyl)acetamide

CRBN

BRD2
BRD4

 Inquiry

Molecular Weight: 730.29

Molecular Formula: C37H40ClN7O5S

Description: It is a potent degrader of bromodomain and extra-terminal (BET) proteins.
(2R,4S)-1-((S)-2-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202443 (2R,4S)-1-((S)-2-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-50-3

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1017.11

Molecular Formula: C50H46F2N10O8S2

Density: 1.49±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(3-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202444 (2R,4S)-1-((S)-2-(3-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-55-8

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1088.19

Molecular Formula: C53H51F2N11O9S2

Density: 1.49±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(4-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202445 (2R,4S)-1-((S)-2-(4-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-56-9

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1102.22

Molecular Formula: C54H53F2N11O9S2

Density: 1.47±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(5-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202446 (2R,4S)-1-((S)-2-(5-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-62-7

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1116.24

Molecular Formula: C55H55F2N11O9S2

Density: 1.46±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(6-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202447 (2R,4S)-1-((S)-2-(6-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-63-8

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1130.27

Molecular Formula: C56H57F2N11O9S2

Density: 1.45±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(7-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202448 (2R,4S)-1-((S)-2-(7-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-64-9

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1144.28

Molecular Formula: C57H59F2N11O9S2

Density: 1.44±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(8-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202449 (2R,4S)-1-((S)-2-(8-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-65-0

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1158.32

Molecular Formula: C58H61F2N11O9S2

Density: 1.43±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-2-(2-(2-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202450 (2R,4S)-1-((S)-2-(2-(2-(2-(5-(6-(5-((2,4-Difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)benzamido)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-70-7

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1118.21

Molecular Formula: C54H53F2N11O10S2

Density: 1.48±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-12-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,10-dioxo-5,8-dioxa-2,11-diazatridecan-13-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202451 (2R,4S)-1-((S)-12-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,10-dioxo-5,8-dioxa-2,11-diazatridecan-13-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-71-8

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1162.27

Molecular Formula: C56H57F2N11O11S2

Density: 1.47±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.
(2R,4S)-1-((S)-15-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-202452 (2R,4S)-1-((S)-15-(tert-Butyl)-1-(2-(5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2766352-79-6

VHL

PI3Kalpha

 Inquiry

Molecular Weight: 1206.32

Molecular Formula: C58H61F2N11O12S2

Density: 1.45±0.1 g/cm3

Description: It is a VHL-based PROTAC that targets the degradation of PI3K kinase.

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