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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)butanamide BPL-202533 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 915.03

Molecular Formula: C47H54N12O8

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
MA071 BPL-202534 MA071

CRBN

Wee1

 Inquiry

Molecular Weight: 959.08

Molecular Formula: C49H58N12O9

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)butanamide BPL-202535 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1003.13

Molecular Formula: C51H62N12O10

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)butanamide BPL-202536 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1047.18

Molecular Formula: C53H66N12O11

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)butanamide BPL-202537 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1091.24

Molecular Formula: C55H70N12O12

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-(2-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-2-oxoethoxy)ethoxy)ethyl)butanamide BPL-202538 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(2-(2-(2-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-2-oxoethoxy)ethoxy)ethyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1016.13

Molecular Formula: C51H61N13O10

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)butanamide BPL-202539 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1060.18

Molecular Formula: C53H65N13O11

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutyl)butanamide BPL-202540 4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)-N-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutyl)butanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 956.08

Molecular Formula: C49H57N13O8

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
6-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)hexanamide BPL-202541 6-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)hexanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 984.13

Molecular Formula: C51H61N13O8

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
8-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)octanamide BPL-202542 8-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)octanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1012.19

Molecular Formula: C53H65N13O8

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
11-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)undecanamide BPL-202543 11-(4-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)butanamido)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)undecanamide

CRBN

Wee1

 Inquiry

Molecular Weight: 1054.27

Molecular Formula: C56H71N13O8

Description: It is a PROTAC using AZD1775 linked to the CRBN ligand pomalidomide. It induces the selective degradation of Wee1.
2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)piperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202544 2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)piperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile

CRBN

AR

 Inquiry

Molecular Weight: 788.35

Molecular Formula: C44H46ClN7O5

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-(8-(4-(4-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)piperidine-1-carbonyl)phenyl)-1-methyl-2,8-diazaspiro[4.5]decan-2-yl)-3-methylbenzonitrile BPL-202545 2-Chloro-4-(8-(4-(4-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)piperidine-1-carbonyl)phenyl)-1-methyl-2,8-diazaspiro[4.5]decan-2-yl)-3-methylbenzonitrile

CRBN

AR

 Inquiry

Molecular Weight: 788.35

Molecular Formula: C44H46ClN7O5

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-(8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)piperidine-1-carbonyl)phenyl)-1-methyl-2,8-diazaspiro[4.5]decan-2-yl)-3-methylbenzonitrile BPL-202546 2-Chloro-4-(8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)piperidine-1-carbonyl)phenyl)-1-methyl-2,8-diazaspiro[4.5]decan-2-yl)-3-methylbenzonitrile

CRBN

AR

 Inquiry

Molecular Weight: 802.38

Molecular Formula: C45H48ClN7O5

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)-4-methoxypiperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202547 2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)-4-methoxypiperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile

CRBN

AR

 Inquiry

Molecular Weight: 818.38

Molecular Formula: C45H48ClN7O6

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(4-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)piperidine-1-carbonyl)phenyl)-3-ethyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202548 2-Chloro-4-((3S)-8-(4-(4-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)piperidine-1-carbonyl)phenyl)-3-ethyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile 2632305-90-7

CRBN

AR

 Inquiry

Molecular Weight: 788.35

Molecular Formula: C44H46ClN7O5

Density: 1.45±0.1 g/cm3

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazine-1-carbonyl)phenyl)-3-ethyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202549 2-Chloro-4-((3S)-8-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazine-1-carbonyl)phenyl)-3-ethyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile 2632305-91-8

CRBN

AR

 Inquiry

Molecular Weight: 803.36

Molecular Formula: C44H47ClN8O5

Density: 1.46±0.1 g/cm3

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(3-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)azetidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202550 2-Chloro-4-((3S)-8-(4-(3-((6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)azetidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile 2632305-93-0

CRBN

AR

 Inquiry

Molecular Weight: 760.29

Molecular Formula: C42H42ClN7O5

Density: 1.48±0.1 g/cm3

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5-oxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)-4-fluoropiperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202551 2-Chloro-4-((3S)-8-(4-(4-((6-(2,6-dioxopiperidin-3-yl)-5-oxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)methyl)-4-fluoropiperidine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile 2632332-90-0

CRBN

AR

 Inquiry

Molecular Weight: 792.36

Molecular Formula: C44H47ClFN7O4

Density: 1.43±0.1 g/cm3

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.
2-Chloro-4-((3S)-8-(4-(2-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)-7-azaspiro[3.5]nonane-7-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile BPL-202552 2-Chloro-4-((3S)-8-(4-(2-(6-(2,6-dioxopiperidin-3-yl)-5,7-dioxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)-7-azaspiro[3.5]nonane-7-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile 2632305-96-3

CRBN

AR

 Inquiry

Molecular Weight: 814.39

Molecular Formula: C46H48ClN7O5

Density: 1.46±0.1 g/cm3

Description: It is a spirocyclic androgen receptor protein degrader used to treat prostate cancer.

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