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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-((3-(2,6-dioxopiperidin-3-yl)phenyl)amino)butyl)benzamide BPL-202413 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-((3-(2,6-dioxopiperidin-3-yl)phenyl)amino)butyl)benzamide 2789678-86-8

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 763.89

Molecular Formula: C38H41N11O5S

Density: 1.48±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-(4-(2,6-dioxopiperidin-3-yl)phenoxy)butyl)benzamide BPL-202414 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-(4-(2,6-dioxopiperidin-3-yl)phenoxy)butyl)benzamide 2789678-87-9

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 764.87

Molecular Formula: C38H40N10O6S

Density: 1.47±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-(3-(2,6-dioxopiperidin-3-yl)phenoxy)butyl)benzamide BPL-202415 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-(3-(2,6-dioxopiperidin-3-yl)phenoxy)butyl)benzamide 2789679-24-7

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 764.87

Molecular Formula: C38H40N10O6S

Density: 1.47±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)benzamide BPL-202416 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)benzamide 2789679-29-2

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 775.89

Molecular Formula: C39H41N11O5S

Density: 1.52±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)benzamide BPL-202417 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)benzamide 2789679-20-3

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 804.94

Molecular Formula: C40H44N12O5S

Density: 1.50±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(5-(4-(2,6-dioxopiperidin-3-yl)phenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)propyl)benzamide BPL-202418 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(5-(4-(2,6-dioxopiperidin-3-yl)phenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)propyl)benzamide 2789679-31-6

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 830.98

Molecular Formula: C42H46N12O5S

Density: 1.54±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(9-(4-(2,6-dioxopiperidin-3-yl)phenyl)-3,9-diazaspiro[5.5]undecan-3-yl)propyl)benzamide BPL-202419 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(9-(4-(2,6-dioxopiperidin-3-yl)phenyl)-3,9-diazaspiro[5.5]undecan-3-yl)propyl)benzamide 2789679-34-9

CRBN

JAK2
JAK3

 Inquiry

Molecular Weight: 887.08

Molecular Formula: C46H54N12O5S

Density: 1.45±0.1 g/cm3

Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
(2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(methylsulfonamido)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202420 (2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(methylsulfonamido)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-20-2

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1043.76

Molecular Formula: C52H67ClN10O7S2

Density: 1.313±0.06 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(N-methylmethylsulfonamido)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202421 (2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(N-methylmethylsulfonamido)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-22-4

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1057.79

Molecular Formula: C53H69ClN10O7S2

Density: 1.301±0.06 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202422 (2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-24-6

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1027.67

Molecular Formula: C52H68ClN10O6PS

Density: 1.33±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202423 (2S,4R)-1-((S)-2-(6-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-26-8

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1057.79

Molecular Formula: C53H69ClN10O7S2

Density: 1.289±0.06 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(4-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202424 (2S,4R)-1-((S)-2-(4-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-28-0

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 999.62

Molecular Formula: C50H64ClN10O6PS

Density: 1.35±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(5-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202425 (2S,4R)-1-((S)-2-(5-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-30-4

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1013.65

Molecular Formula: C51H66ClN10O6PS

Density: 1.34±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(7-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202426 (2S,4R)-1-((S)-2-(7-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-32-6

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1041.69

Molecular Formula: C53H70ClN10O6PS

Density: 1.32±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(8-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202427 (2S,4R)-1-((S)-2-(8-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-34-8

VHL

EGFR del19/T790M/C797S
EGFR e19d
EGFR L858R/T790M

 Inquiry

Molecular Weight: 1055.73

Molecular Formula: C54H72ClN10O6PS

Density: 1.31±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
(2S,4R)-1-((S)-2-(9-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202428 (2S,4R)-1-((S)-2-(9-(4-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2764870-36-0

VHL

EGFR del19/T790M/C797S

 Inquiry

Molecular Weight: 1069.76

Molecular Formula: C55H74ClN10O6PS

Density: 1.30±0.1 g/cm3

Description: It is a novel EGFR PROTAC targeting Del19/T790M/C797S mutation.
SD-91 BPL-202429 SD-91 2497583-03-4

CRBN

STAT3

 Inquiry

Molecular Weight: 1136.17

Molecular Formula: C59H62N9O13P

Density: 1.49±0.1 g/cm3

Description: SD-91 is a potent and selective STAT3 degrader capable of achieving complete and long-lasting tumor regression.
(2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202430 (2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

VHL

FAK

 Inquiry

Molecular Weight: 1161.36

Molecular Formula: C58H75F3N10O10S

Description: It is a highly cooperative FAK-degrading PROTAC.
(2S,4R)-4-Hydroxy-1-((S)-2-(11-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)undecanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202431 (2S,4R)-4-Hydroxy-1-((S)-2-(11-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)undecanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

VHL

FAK

 Inquiry

Molecular Weight: 1111.39

Molecular Formula: C59H77F3N10O6S

Description: It is a highly cooperative FAK-degrading PROTAC.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-202432 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

VHL

FAK

 Inquiry

Molecular Weight: 1073.25

Molecular Formula: C54H67F3N10O8S

Description: It is a highly cooperative FAK-degrading PROTAC.

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