PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202393	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide	2653335-24-9	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 809.24 Molecular Formula: C40H37ClN8O9 Density: 1.474±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202394	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)acetamide	2653335-25-0	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 853.29 Molecular Formula: C42H41ClN8O10 Density: 1.450±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202395	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)acetamide	2653335-26-1	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 897.34 Molecular Formula: C44H45ClN8O11 Density: 1.429±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202396	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)acetamide	2653335-27-2	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 941.39 Molecular Formula: C46H49ClN8O12 Density: 1.411±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202397	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(20-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxaicosyl)acetamide	2653335-28-3	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 985.45 Molecular Formula: C48H53ClN8O13 Density: 1.395±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202398	2-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(23-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21-heptaoxatricosyl)acetamide	2653335-29-4	CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 1029.50 Molecular Formula: C50H57ClN8O14 Density: 1.380±0.06 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202399	1-((1s,4s)-4-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)urea		CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 832.32 Molecular Formula: C43H42ClN9O7 Density: 1.49±0.1 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202400	1-((1s,4s)-4-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)urea		CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 892.37 Molecular Formula: C45H46ClN9O9 Density: 1.48±0.1 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202401	1-((1s,4s)-4-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)urea		CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 936.42 Molecular Formula: C47H50ClN9O10 Density: 1.46±0.1 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202402	1-((1s,4s)-4-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)urea		CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 980.48 Molecular Formula: C49H54ClN9O11 Density: 1.45±0.1 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202403	1-((1s,4s)-4-((5-(2-Chloro-4-phenoxybenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)urea		CRBN	BTK BTK C481S	Inquiry
Molecular Weight: 1024.53 Molecular Formula: C51H58ClN9O12 Density: 1.43±0.1 g/cm3 Description: It is a BTK PROTAC using the selective non-covalent BTK inhibitor ARQ531 as warhead. It can improve the degradation of wild-type and C481S mutant BTKS and increase the selectivity of BTK over other kinases.
	BPL-202404	4-((((2Z,3E)-1'-((1-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide		CRBN	HDAC6	Inquiry
Molecular Weight: 802.81 Molecular Formula: C40H38N10O9 Melting Point: 125.1-129.0°C Density: 1.58±0.1 g/cm3 Description: It is an HDAC6 degrader with low cytotoxicity by tethering a selective HDAC6 inhibitor derived from a natural product, indirubin, with pomalidomide, a CRBN E3 ligand. It efficiently and selectively reduces HDAC6 levels in several cell lines, including activated THP-1 cells.
	BPL-202405	4-((((2Z,3E)-1'-((1-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide		CRBN	HDAC6	Inquiry
Molecular Weight: 846.86 Molecular Formula: C42H42N10O10 Melting Point: 112.1-115.3°C Density: 1.55±0.1 g/cm3 Description: It is an HDAC6 degrader with low cytotoxicity by tethering a selective HDAC6 inhibitor derived from a natural product, indirubin, with pomalidomide, a CRBN E3 ligand. It efficiently and selectively reduces HDAC6 levels in several cell lines, including activated THP-1 cells.
	BPL-202406	4-((((2Z,3E)-1'-((1-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide		CRBN	HDAC6	Inquiry
Molecular Weight: 890.91 Molecular Formula: C44H46N10O11 Melting Point: 97.3-99.2°C Density: 1.53±0.1 g/cm3 Description: It is an HDAC6 degrader with low cytotoxicity by tethering a selective HDAC6 inhibitor derived from a natural product, indirubin, with pomalidomide, a CRBN E3 ligand. It efficiently and selectively reduces HDAC6 levels in several cell lines, including activated THP-1 cells.
	BPL-202407	4-((((2Z,3E)-1'-((1-(14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide		CRBN	HDAC6	Inquiry
Molecular Weight: 934.96 Molecular Formula: C46H50N10O12 Melting Point: 72.3-74.7°C Density: 1.50±0.1 g/cm3 Description: It is an HDAC6 degrader with low cytotoxicity by tethering a selective HDAC6 inhibitor derived from a natural product, indirubin, with pomalidomide, a CRBN E3 ligand. It efficiently and selectively reduces HDAC6 levels in several cell lines, including activated THP-1 cells.
	BPL-202408	4-((((2Z,3E)-1'-((1-(17-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)methyl)-2'-oxo-[2,3'-biindolinylidene]-3-ylidene)amino)oxy)-N-hydroxybutanamide		CRBN	HDAC6	Inquiry
Molecular Weight: 979.02 Molecular Formula: C48H54N10O13 Melting Point: 82.1-85.3°C Density: 1.48±0.1 g/cm3 Description: It is an HDAC6 degrader with low cytotoxicity by tethering a selective HDAC6 inhibitor derived from a natural product, indirubin, with pomalidomide, a CRBN E3 ligand. It efficiently and selectively reduces HDAC6 levels in several cell lines, including activated THP-1 cells.
	BPL-202409	SJ001005354		CRBN	JAK2 JAK3	Inquiry
Molecular Weight: 832.90 Molecular Formula: C40H40N12O7S Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
	BPL-202410	4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)butyl)benzamide		CRBN	JAK2 JAK3	Inquiry
Molecular Weight: 833.89 Molecular Formula: C40H39N11O8S Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
	BPL-202411	4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)benzamide	2789679-12-3	CRBN	JAK2 JAK3	Inquiry
Molecular Weight: 844.92 Molecular Formula: C41H40N12O7S Density: 1.63±0.1 g/cm3 Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.
	BPL-202412	SJ001008030	2863634-96-0	CRBN	JAK2 JAK3	Inquiry
Molecular Weight: 873.96 Molecular Formula: C42H43N13O7S Density: 1.60±0.1 g/cm3 Description: It is a potent and selective Janus Kinase 2/3 directing PG-PROTAC utilizing a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter.