PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202353	N-(2-Chloro-6-methylphenyl)-2-((6-(4-(5-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-5-oxopentanoyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide	2376047-61-7	CRBN	BCR-ABL	Inquiry
Molecular Weight: 799.31 Molecular Formula: C38H39ClN10O6S Density: 1.483±0.06 g/cm3 Description: It is a BCR-ABL PROTAC synthesized by conjugating BCR-ABL inhibitor dasatinib to the CRBN ligand including pomalidomide and lenalidomide.
	BPL-202354	Ethyl 3-(1-(N-benzyl-5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-ynamido)-2-(tert-butylamino)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-64-2	CRBN	MDM2	Inquiry
Molecular Weight: 764.28 Molecular Formula: C42H42ClN5O7 Boiling Point: 1033.3±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202355	Ethyl 3-(1-(N-benzyl-6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynamido)-2-(tert-butylamino)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-65-3	CRBN	MDM2	Inquiry
Molecular Weight: 778.31 Molecular Formula: C43H44ClN5O7 Boiling Point: 1036.0±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202356	Ethyl 3-(1-(N-benzyl-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynamido)-2-(tert-butylamino)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-66-4	CRBN	MDM2	Inquiry
Molecular Weight: 792.33 Molecular Formula: C44H46ClN5O7 Boiling Point: 1039.0±65.0°C at 760 Torr Density: 1.36±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202357	Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)-5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-67-5	CRBN	MDM2	Inquiry
Molecular Weight: 798.72 Molecular Formula: C42H41Cl2N5O7 Boiling Point: 1048.7±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202358	Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)-6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-68-6	CRBN	MDM2	Inquiry
Molecular Weight: 812.75 Molecular Formula: C43H43Cl2N5O7 Boiling Point: 1051.3±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202359	Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)-7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-69-7	CRBN	MDM2	Inquiry
Molecular Weight: 826.78 Molecular Formula: C44H45Cl2N5O7 Boiling Point: 1054.2±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202360	Ethyl 3-(2-(tert-butylamino)-1-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)pent-4-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-70-0	CRBN	MDM2	Inquiry
Molecular Weight: 818.25 Molecular Formula: C42H39ClF3N5O7 Boiling Point: 1037.8±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202361	Ethyl 3-(2-(tert-butylamino)-1-(6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hex-5-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-71-1	CRBN	MDM2	Inquiry
Molecular Weight: 832.28 Molecular Formula: C43H41ClF3N5O7 Boiling Point: 1040.6±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202362	WB214	2640723-72-2	CRBN	MDM2	Inquiry
Molecular Weight: 846.29 Molecular Formula: C44H43ClF3N5O7 Boiling Point: 1043.6±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: WB214 is the most potent anti-proliferative agent in various leukemia cell lines. WB214 can effectively induce the degradation of MDM2 and lead to the degradation of p53. WB214 degrades MDM2 as a molecular glue. WB214 can potently degrade GSPT1, which can rationalize the inhibition of cell growth.
	BPL-202363	Ethyl 3-(2-(tert-butylamino)-1-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)oct-7-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-73-3	CRBN	MDM2	Inquiry
Molecular Weight: 860.33 Molecular Formula: C45H45ClF3N5O7 Boiling Point: 1046.8±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202364	Ethyl 3-(2-(tert-butylamino)-1-(9-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)non-8-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-74-4	CRBN	MDM2	Inquiry
Molecular Weight: 874.36 Molecular Formula: C46H47ClF3N5O7 Boiling Point: 1050.2±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202365	Ethyl 3-(2-(tert-butylamino)-1-(10-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)dec-9-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-75-5	CRBN	MDM2	Inquiry
Molecular Weight: 888.38 Molecular Formula: C47H49ClF3N5O7 Boiling Point: 1053.9±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202366	Ethyl 3-(2-(tert-butylamino)-1-(11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)undec-10-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate	2640723-76-6	CRBN	MDM2	Inquiry
Molecular Weight: 902.41 Molecular Formula: C48H51ClF3N5O7 Boiling Point: 1057.7±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202367	3-(2-(tert-Butylamino)-1-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylic acid	2640723-77-7	CRBN	MDM2	Inquiry
Molecular Weight: 818.25 Molecular Formula: C42H39ClF3N5O7 Boiling Point: 1075.6±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202368	3-(2-(tert-Butylamino)-1-(7-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-N-(3,4,5-trifluorobenzyl)hept-6-ynamido)-2-oxoethyl)-6-chloro-N-ethyl-1H-indole-2-carboxamide	2640723-78-8	CRBN	MDM2	Inquiry
Molecular Weight: 845.32 Molecular Formula: C44H44ClF3N6O6 Boiling Point: 1084.5±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202369	3-(2-(tert-Butylamino)-2-oxo-1-(N-(3,4,5-trifluorobenzyl)formamido)ethyl)-6-chloro-N-(3-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)prop-2-yn-1-yl)-1H-indole-2-carboxamide	2640723-79-9	CRBN	MDM2	Inquiry
Molecular Weight: 775.18 Molecular Formula: C39H34ClF3N6O6 Boiling Point: 1092.7±65.0°C at 760 Torr Density: 1.50±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202370	3-(2-(tert-Butylamino)-2-oxo-1-(N-(3,4,5-trifluorobenzyl)formamido)ethyl)-6-chloro-N-(4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)but-3-yn-1-yl)-1H-indole-2-carboxamide	2640723-80-2	CRBN	MDM2	Inquiry
Molecular Weight: 789.21 Molecular Formula: C40H36ClF3N6O6 Boiling Point: 1099.4±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202371	3-(2-(tert-Butylamino)-2-oxo-1-(N-(3,4,5-trifluorobenzyl)formamido)ethyl)-6-chloro-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)-1H-indole-2-carboxamide	2640723-81-3	CRBN	MDM2	Inquiry
Molecular Weight: 803.24 Molecular Formula: C41H38ClF3N6O6 Boiling Point: 1103.4±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.
	BPL-202372	3-(2-(tert-Butylamino)-2-oxo-1-(N-(3,4,5-trifluorobenzyl)formamido)ethyl)-6-chloro-N-(6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-yn-1-yl)-1H-indole-2-carboxamide	2640723-82-4	CRBN	MDM2	Inquiry
Molecular Weight: 817.27 Molecular Formula: C42H40ClF3N6O6 Boiling Point: 1106.3±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an MDM2 degrader based on ligand.