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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]amino]benzamide BPL-202173 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]amino]benzamide 2757424-04-5

CRBN

AR

 Inquiry

Molecular Weight: 711.22

Molecular Formula: C38H39ClN6O6

Boiling Point: 1003.0±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]hexyl]amino]benzamide BPL-202174 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]hexyl]amino]benzamide 2757424-05-6

CRBN

AR

 Inquiry

Molecular Weight: 725.25

Molecular Formula: C39H41ClN6O6

Boiling Point: 1005.3±65.0°C at 760 Torr

Density: 1.38±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]heptyl]amino]benzamide BPL-202175 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]heptyl]amino]benzamide 2757424-06-7

CRBN

AR

 Inquiry

Molecular Weight: 739.27

Molecular Formula: C40H43ClN6O6

Boiling Point: 1008.0±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]octyl]amino]benzamide BPL-202176 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]octyl]amino]benzamide 2757424-07-8

CRBN

AR

 Inquiry

Molecular Weight: 753.30

Molecular Formula: C41H45ClN6O6

Boiling Point: 1011.0±65.0°C at 760 Torr

Density: 1.35±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]nonyl]amino]benzamide BPL-202177 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]nonyl]amino]benzamide 2757424-08-9

CRBN

AR

 Inquiry

Molecular Weight: 767.33

Molecular Formula: C42H47ClN6O6

Boiling Point: 996.1±65.0°C at 760 Torr

Density: 1.34±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]decyl]amino]benzamide BPL-202178 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]decyl]amino]benzamide 2757424-09-0

CRBN

AR

 Inquiry

Molecular Weight: 781.35

Molecular Formula: C43H49ClN6O6

Boiling Point: 1000.0±65.0°C at 760 Torr

Density: 1.33±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]undecyl]amino]benzamide BPL-202179 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[[11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]undecyl]amino]benzamide 2757424-10-3

CRBN

AR

 Inquiry

Molecular Weight: 795.38

Molecular Formula: C44H51ClN6O6

Boiling Point: 1004.1±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethyl]-1-piperazinyl]benzamide BPL-202180 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethyl]-1-piperazinyl]benzamide 2757424-11-4

CRBN

AR

 Inquiry

Molecular Weight: 738.25

Molecular Formula: C39H40ClN7O6

Boiling Point: 1010.2±65.0°C at 760 Torr

Density: 1.45±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]propyl]-1-piperazinyl]benzamide BPL-202181 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]propyl]-1-piperazinyl]benzamide 2757424-12-5

CRBN

AR

 Inquiry

Molecular Weight: 752.27

Molecular Formula: C40H42ClN7O6

Boiling Point: 1014.9±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]butyl]-1-piperazinyl]benzamide BPL-202182 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]butyl]-1-piperazinyl]benzamide 2757424-13-6

CRBN

AR

 Inquiry

Molecular Weight: 766.30

Molecular Formula: C41H44ClN7O6

Boiling Point: 1016.3±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]-1-piperazinyl]benzamide BPL-202183 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]-1-piperazinyl]benzamide 2757424-14-7

CRBN

AR

 Inquiry

Molecular Weight: 780.33

Molecular Formula: C42H46ClN7O6

Boiling Point: 1019.4±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinyl]benzamide BPL-202184 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinyl]benzamide 2757423-00-8

CRBN

AR

 Inquiry

Molecular Weight: 792.34

Molecular Formula: C43H46ClN7O6

Boiling Point: 1023.4±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]-1-piperazinyl]benzamide BPL-202185 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]-1-piperazinyl]benzamide 2222112-81-2

CRBN

AR

 Inquiry

Molecular Weight: 778.31

Molecular Formula: C42H44ClN7O6

Boiling Point: 1019.5±65.0°C at 760 Torr

Density: 1.44±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide BPL-202186 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide 2222112-80-1

CRBN

AR
AR T878A

 Inquiry

Molecular Weight: 778.31

Molecular Formula: C42H44ClN7O6

Boiling Point: 1019.5±65.0°C at 760 Torr

Density: 1.44±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]methyl]-1-piperazinyl]benzamide BPL-202187 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]methyl]-1-piperazinyl]benzamide 2757424-16-9

CRBN

AR
AR T878A

 Inquiry

Molecular Weight: 764.28

Molecular Formula: C41H42ClN7O6

Boiling Point: 1014.5±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]benzamide BPL-202188 N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]benzamide 2757422-70-9

CRBN

AR

 Inquiry

Molecular Weight: 750.26

Molecular Formula: C40H40ClN7O6

Boiling Point: 1011.0±65.0°C at 760 Torr

Density: 1.48±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[(1S,3S)-3-(3-Chloro-4-cyanophenoxy)cyclopentyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide BPL-202189 N-[(1S,3S)-3-(3-Chloro-4-cyanophenoxy)cyclopentyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide 2757424-17-0

CRBN

AR

 Inquiry

Molecular Weight: 764.28

Molecular Formula: C41H42ClN7O6

Boiling Point: 1012.6±65.0°C at 760 Torr

Density: 1.46±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[(1R,4R)-4-(3-Chloro-4-cyanophenoxy)cycloheptyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide BPL-202190 N-[(1R,4R)-4-(3-Chloro-4-cyanophenoxy)cycloheptyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide 2830636-12-7

CRBN

AR

 Inquiry

Molecular Weight: 792.34

Molecular Formula: C43H46ClN7O6

Boiling Point: 1024.0±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
N-[trans-5-(3-Chloro-4-cyanophenoxy)cyclooctyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide BPL-202191 N-[trans-5-(3-Chloro-4-cyanophenoxy)cyclooctyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide 2757424-19-2

CRBN

AR

 Inquiry

Molecular Weight: 806.36

Molecular Formula: C44H48ClN7O6

Boiling Point: 1028.7±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
2-Chloro-4-[[1-[4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzoyl]-4-piperidinyl]oxy]benzonitrile BPL-202192 2-Chloro-4-[[1-[4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzoyl]-4-piperidinyl]oxy]benzonitrile 2757571-61-0

CRBN

AR

 Inquiry

Molecular Weight: 764.28

Molecular Formula: C41H42ClN7O6

Boiling Point: 981.4±65.0°C at 760 Torr

Density: 1.47±0.1 g/cm3

Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.

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