PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202253	(2S,4R)-1-((S)-2-(7-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-13-6	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1011.26 Molecular Formula: C51H70N12O8S Density: 1.33±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202254	(2S,4R)-1-((S)-2-(8-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-15-8	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1025.29 Molecular Formula: C52H72N12O8S Density: 1.32±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202255	(2S,4R)-1-((S)-2-(9-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-17-0	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1039.32 Molecular Formula: C53H74N12O8S Density: 1.31±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202256	(2S,4R)-1-((S)-2-(10-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-19-2	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1053.34 Molecular Formula: C54H76N12O8S Density: 1.31±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202257	(2S,4R)-1-((S)-2-(11-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-21-6	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1067.37 Molecular Formula: C55H78N12O8S Density: 1.30±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202258	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)butanamide	2376139-23-8	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 813.87 Molecular Formula: C39H47N11O9 Density: 1.48±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202259	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)butanamide	2376139-25-0	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 857.93 Molecular Formula: C41H51N11O10 Density: 1.46±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202260	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)butanamide	2376139-27-2	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 901.98 Molecular Formula: C43H55N11O11 Density: 1.44±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202261	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)butanamide	2376139-29-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 946.03 Molecular Formula: C45H59N11O12 Density: 1.42±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202262	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)butanamide	2376139-31-8	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 990.09 Molecular Formula: C47H63N11O13 Density: 1.40±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202263	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)butanamide	2376139-33-0	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 769.82 Molecular Formula: C37H43N11O8 Density: 1.50±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202264	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)butanamide	2376139-35-2	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 783.85 Molecular Formula: C38H45N11O8 Density: 1.48±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202265	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)butanamide	2376139-37-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 797.87 Molecular Formula: C39H47N11O8 Density: 1.47±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202266	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)butanamide	2376139-39-6	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 811.89 Molecular Formula: C40H49N11O8 Density: 1.45±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202267	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)butanamide	2376139-41-0	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 825.93 Molecular Formula: C41H51N11O8 Density: 1.43±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202268	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptyl)butanamide	2376139-43-2	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 839.96 Molecular Formula: C42H53N11O8 Density: 1.42±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202269	4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)butanamide	2376139-45-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 853.98 Molecular Formula: C43H55N11O8 Density: 1.40±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202270	N1-(2-(((E)-4-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-4-oxobut-2-en-1-yl)(methyl)amino)ethyl)-N5-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N1-methylglutaramide	2768472-10-0	VHL	EGFR e19d EGFR L858R/T790M	Inquiry
Molecular Weight: 1126.44 Molecular Formula: C60H79N13O7S Density: 1.26±0.1 g/cm3 Description: It is a potent PROTAC targeting EGFR mutants by optimizing covalent EGFR ligands.
	BPL-202271	N1-(2-(((E)-4-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-4-oxobut-2-en-1-yl)(methyl)amino)ethyl)-N7-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N1-methylheptanediamide	2768472-11-1	VHL	EGFR e19d EGFR L858R/T790M	Inquiry
Molecular Weight: 1154.47 Molecular Formula: C62H83N13O7S Density: 1.24±0.1 g/cm3 Description: It is a potent PROTAC targeting EGFR mutants by optimizing covalent EGFR ligands.
	BPL-202272	N1-(2-(((E)-4-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-4-oxobut-2-en-1-yl)(methyl)amino)ethyl)-N8-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N1-methyloctanediamide	2768472-12-2	VHL	EGFR e19d EGFR L858R/T790M	Inquiry
Molecular Weight: 1168.52 Molecular Formula: C63H85N13O7S Density: 1.24±0.1 g/cm3 Description: It is a potent PROTAC targeting EGFR mutants by optimizing covalent EGFR ligands.