PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202213	2-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)acetamide	2619793-07-4	CRBN	ALK	Inquiry
Molecular Weight: 866.04 Molecular Formula: C49H55N9O6 Density: 1.40±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202214	2-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)acetamide	2619793-09-6	CRBN	ALK	Inquiry
Molecular Weight: 894.09 Molecular Formula: C51H59N9O6 Density: 1.38±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202215	(2S,4R)-1-((2S,15S)-2-(tert-Butyl)-15-(4-chlorophenyl)-16-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-4,10,16-trioxo-6-oxa-3,9,13-triazahexadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-18-2	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1001.65 Molecular Formula: C50H65ClN10O8S Boiling Point: 1228.3±65.0°C at 760 Torr Density: 1.317±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202216	(2S,4R)-1-((2S,18S)-2-(tert-Butyl)-18-(4-chlorophenyl)-19-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-4,13,19-trioxo-6,9-dioxa-3,12,16-triazanonadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-20-6	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1045.69 Molecular Formula: C52H69ClN10O9S Boiling Point: 1243.6±65.0°C at 760 Torr Density: 1.308±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202217	(2S,4R)-1-((2S,25S)-2-(tert-Butyl)-25-(4-chlorophenyl)-26-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-4,20,26-trioxo-7,10,13,16-tetraoxa-3,19,23-triazahexacosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-22-8	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1147.84 Molecular Formula: C57H79ClN10O11S Boiling Point: 1282.4±65.0°C at 760 Torr Density: 1.283±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202218	(2S,4R)-1-((S)-2-(5-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-24-0	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 999.68 Molecular Formula: C51H67ClN10O7S Boiling Point: 1227.8±65.0°C at 760 Torr Density: 1.298±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202219	(2S,4R)-1-((S)-2-(6-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-26-2	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1013.71 Molecular Formula: C52H69ClN10O7S Boiling Point: 1230.2±65.0°C at 760 Torr Density: 1.288±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202220	(2S,4R)-1-((S)-2-(7-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-28-4	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1027.73 Molecular Formula: C53H71ClN10O7S Boiling Point: 1232.7±65.0°C at 760 Torr Density: 1.279±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202221	(2S,4R)-1-((S)-2-(9-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-30-8	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1055.79 Molecular Formula: C55H75ClN10O7S Boiling Point: 1238.2±65.0°C at 760 Torr Density: 1.262±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202222	(2S,4R)-1-((S)-2-(10-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-32-0	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1069.81 Molecular Formula: C56H77ClN10O7S Boiling Point: 1235.8±65.0°C at 760 Torr Density: 1.254±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202223	(2S,4R)-1-((S)-2-(11-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376136-34-2	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1083.84 Molecular Formula: C57H79ClN10O7S Boiling Point: 1238.9±65.0°C at 760 Torr Density: 1.246±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202224	(2S,4R)-1-((S)-2-(11-(3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)propanamido)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide	2376136-36-4	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1097.87 Molecular Formula: C58H81ClN10O7S Boiling Point: 1236.3±65.0°C at 760 Torr Density: 1.238±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202225	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)propanamide	2376136-38-6	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 830.34 Molecular Formula: C41H48ClN9O8 Boiling Point: 1111.4±65.0°C at 760 Torr Density: 1.409±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202226	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)propanamide	2376136-40-0	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 874.39 Molecular Formula: C43H52ClN9O9 Boiling Point: 1121.4±65.0°C at 760 Torr Density: 1.390±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202227	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)propanamide	2376136-42-2	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 918.45 Molecular Formula: C45H56ClN9O10 Boiling Point: 1132.4±65.0°C at 760 Torr Density: 1.374±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202228	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)propanamide	2376136-44-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 962.49 Molecular Formula: C47H60ClN9O11 Boiling Point: 1144.1±65.0°C at 760 Torr Density: 1.360±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202229	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)propanamide	2376136-46-6	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1006.55 Molecular Formula: C49H64ClN9O12 Boiling Point: 1156.5±65.0°C at 760 Torr Density: 1.347±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202230	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)propanamide	2376136-48-8	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 786.29 Molecular Formula: C39H44ClN9O7 Boiling Point: 1101.4±65.0°C at 760 Torr Density: 1.429±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202231	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)propanamide	2376136-50-2	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 800.32 Molecular Formula: C40H46ClN9O7 Boiling Point: 1103.7±65.0°C at 760 Torr Density: 1.413±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202232	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)propanamide	2376136-52-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 814.34 Molecular Formula: C41H48ClN9O7 Boiling Point: 1105.8±65.0°C at 760 Torr Density: 1.397±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.