PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202233	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)propanamide	2376136-54-6	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 828.37 Molecular Formula: C42H50ClN9O7 Boiling Point: 1107.4±65.0°C at 760 Torr Density: 1.382±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202234	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)propanamide	2376136-56-8	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 842.39 Molecular Formula: C43H52ClN9O7 Boiling Point: 1109.4±65.0°C at 760 Torr Density: 1.367±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202235	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptyl)propanamide	2376136-59-1	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 856.43 Molecular Formula: C44H54ClN9O7 Boiling Point: 1111.6±65.0°C at 760 Torr Density: 1.354±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202236	N-(2-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)ethyl)-9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanamide	2376137-37-8	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 870.45 Molecular Formula: C45H56ClN9O7 Boiling Point: 1113.3±65.0°C at 760 Torr Density: 1.341±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202237	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)nonyl)propanamide	2376137-39-0	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 869.46 Molecular Formula: C46H57ClN8O7 Boiling Point: 1083.8±65.0°C at 760 Torr Density: 1.312±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202238	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)octyl)propanamide	2376137-33-4	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 856.47 Molecular Formula: C45H58ClN9O6 Boiling Point: 1119.2±65.0°C at 760 Torr Density: 1.312±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202239	3-(((S)-2-(4-Chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide	2376137-35-6	CRBN	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 871.44 Molecular Formula: C45H55ClN8O8 Boiling Point: 1095.4±65.0°C at 760 Torr Density: 1.333±0.06 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202240	(2S,4R)-1-((S)-17-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,10-dioxo-6-oxa-3,9,14-triazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-87-1	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 985.18 Molecular Formula: C48H64N12O9S Density: 1.38±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202241	(2S,4R)-1-((S)-18-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,11-dioxo-7-oxa-3,10,15-triazaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-89-3	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 999.21 Molecular Formula: C49H66N12O9S Density: 1.36±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202242	(2S,4R)-1-((S)-20-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,13-dioxo-6,9-dioxa-3,12,17-triazaicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-91-7	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1029.23 Molecular Formula: C50H68N12O10S Density: 1.36±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202243	(2S,4R)-1-((S)-21-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,14-dioxo-7,10-dioxa-3,13,18-triazahenicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-93-9	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1043.26 Molecular Formula: C51H70N12O10S Density: 1.35±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202244	(2S,4R)-1-((S)-23-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,16-dioxo-6,9,12-trioxa-3,15,20-triazatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-95-1	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1073.29 Molecular Formula: C52H72N12O11S Density: 1.35±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202245	(2S,4R)-1-((S)-24-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,17-dioxo-7,10,13-trioxa-3,16,21-triazatetracosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-97-3	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1087.31 Molecular Formula: C53H74N12O11S Density: 1.34±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202246	(2S,4R)-1-((S)-27-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,20-dioxo-7,10,13,16-tetraoxa-3,19,24-triazaheptacosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376138-99-5	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1131.37 Molecular Formula: C55H78N12O12S Density: 1.33±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202247	(2S,4R)-1-((S)-30-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)-2-(tert-butyl)-4,23-dioxo-7,10,13,16,19-pentaoxa-3,22,27-triazatriacontanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-01-2	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 1175.42 Molecular Formula: C57H82N12O13S Density: 1.33±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202248	(2S,4R)-1-((S)-2-(2-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-03-4	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 941.13 Molecular Formula: C46H60N12O8S Density: 1.39±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202249	(2S,4R)-1-((S)-2-(3-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-05-6	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 955.16 Molecular Formula: C47H62N12O8S Density: 1.38±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202250	(2S,4R)-1-((S)-2-(4-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-07-8	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 969.18 Molecular Formula: C48H64N12O8S Density: 1.36±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202251	(2S,4R)-1-((S)-2-(5-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-09-0	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 983.21 Molecular Formula: C49H66N12O8S Density: 1.35±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.
	BPL-202252	(2S,4R)-1-((S)-2-(6-(4-((3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl)oxy)propyl)amino)butanamido)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2376139-11-4	VHL	AKT1 AKT2 AKT3	Inquiry
Molecular Weight: 997.24 Molecular Formula: C50H68N12O8S Density: 1.34±0.1 g/cm3 Description: It is a potent, selective, and bioavailable AKT kinase degrader.