PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-202193	2-Chloro-4-[[1-[4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzoyl]hexahydro-1H-azepin-4-yl]oxy]benzonitrile	2757571-62-1	CRBN	AR	Inquiry
Molecular Weight: 778.31 Molecular Formula: C42H44ClN7O6 Boiling Point: 986.6±65.0°C at 760 Torr Density: 1.45±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202194	N-[trans-4-[(3-Chloro-4-cyanophenyl)amino]cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide	2757424-20-5	CRBN	AR	Inquiry
Molecular Weight: 777.33 Molecular Formula: C42H45ClN8O5 Boiling Point: 1033.5±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202195	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide	2757424-21-6	CRBN	AR AR T878A	Inquiry
Molecular Weight: 791.35 Molecular Formula: C43H47ClN8O5 Boiling Point: 1041.0±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202196	N-[trans-4-[(3-Chloro-4-cyanophenyl)ethylamino]cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide	2757424-22-7	CRBN	AR	Inquiry
Molecular Weight: 805.38 Molecular Formula: C44H49ClN8O5 Boiling Point: 1044.0±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202197	N-[trans-4-[(3-Chloro-4-cyanophenyl)propylamino]cyclohexyl]-4-[4-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-piperidinyl]benzamide	2757424-23-8	CRBN	AR	Inquiry
Molecular Weight: 819.41 Molecular Formula: C45H51ClN8O5 Boiling Point: 1047.2±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202198	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinyl]benzamide	2757422-77-6	CRBN	AR	Inquiry
Molecular Weight: 805.38 Molecular Formula: C44H49ClN8O5 Boiling Point: 1044.8±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202199	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]benzamide	2757424-24-9	CRBN	AR	Inquiry
Molecular Weight: 805.38 Molecular Formula: C44H49ClN8O5 Boiling Point: 1044.8±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202200	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]-1-piperazinyl]benzamide	2757422-78-7	CRBN	AR AR T878A	Inquiry
Molecular Weight: 791.35 Molecular Formula: C43H47ClN8O5 Boiling Point: 1041.0±65.0°C at 760 Torr Density: 1.42±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202201	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]methyl]-1-piperazinyl]benzamide	2757424-25-0	CRBN	AR AR T878A	Inquiry
Molecular Weight: 777.33 Molecular Formula: C42H45ClN8O5 Boiling Point: 1036.1±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202202	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[3-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-azetidinyl]benzamide	2757424-26-1	CRBN	AR AR T878A	Inquiry
Molecular Weight: 777.33 Molecular Formula: C42H45ClN8O5 Boiling Point: 1036.1±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202203	N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[3-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-1-azetidinyl]benzamide	2757424-27-2	CRBN	AR AR T878A	Inquiry
Molecular Weight: 763.29 Molecular Formula: C41H43ClN8O5 Boiling Point: 1032.7±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202204	N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[[4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]-1-piperazinyl]phenyl]sulfonyl]-2-hydroxy-2-methylpropanamide	2757424-28-3	CRBN	AR	Inquiry
Molecular Weight: 835.86 Molecular Formula: C40H40F3N7O8S Boiling Point: 1068.0±65.0°C at 760 Torr Density: 1.55±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202205	4-[3-[4-[[4-[1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]-1-piperazinyl]carbonyl]-3-fluorophenyl]-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile	2757422-68-5	CRBN	AR	Inquiry
Molecular Weight: 858.88 Molecular Formula: C42H38F4N8O6S Density: 1.57±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202206	5-(5-(4-(4-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)piperazine-1-carbonyl)-3-fluorophenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile	2757424-29-4	CRBN	AR	Inquiry
Molecular Weight: 871.87 Molecular Formula: C42H37F4N9O6S Density: 1.62±0.1 g/cm3 Description: It is an exceptionally potent and orally bioavailable PROTAC degrader of androgen receptor.
	BPL-202207	8-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	2619792-49-1	CRBN	ALK	Inquiry
Molecular Weight: 654.73 Molecular Formula: C38H34N6O5 Boiling Point: 961.7±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202208	2-(4-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperazin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide	2619792-50-4	CRBN	ALK	Inquiry
Molecular Weight: 754.85 Molecular Formula: C42H42N8O6 Boiling Point: 1081.6±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202209	2-(4-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperazin-1-yl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)acetamide	2619792-52-6	CRBN	ALK	Inquiry
Molecular Weight: 782.89 Molecular Formula: C44H46N8O6 Boiling Point: 1085.0±65.0°C at 760 Torr Density: 1.43±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202210	2-(4-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperazin-1-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)acetamide	2619792-54-8	CRBN	ALK	Inquiry
Molecular Weight: 810.96 Molecular Formula: C46H50N8O6 Boiling Point: 1089.1±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202211	8-(4-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	2619793-04-1	CRBN	ALK	Inquiry
Molecular Weight: 737.86 Molecular Formula: C43H43N7O5 Density: 1.45±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).
	BPL-202212	2-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide	2619793-05-2	CRBN	ALK	Inquiry
Molecular Weight: 837.98 Molecular Formula: C47H51N9O6 Density: 1.43±0.1 g/cm3 Description: It is an Alectinib-based PROTAC as a novel potent degrader of anaplastic lymphoma kinase (ALK).