PROTAC Library

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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
NR-6a BPL-201513 NR-6a 2550398-87-1

CRBN

p38alpha
p38beta

Inquiry

Molecular Weight: 997.94

Molecular Formula: C50H55BrF2N8O7

Density: 1.43±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α and p38β degradation.

NR-6b BPL-201514 NR-6b 2550398-63-3

CRBN

p38alpha

Inquiry

Molecular Weight: 983.91

Molecular Formula: C49H53BrF2N8O7

Density: 1.44±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7a BPL-201515 NR-7a 2550398-66-6

CRBN

p38alpha

Inquiry

Molecular Weight: 942.78

Molecular Formula: C44H42BrF2N9O8

Density: 1.56±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7b BPL-201516 NR-7b 2550398-18-8

CRBN

p38alpha

Inquiry

Molecular Weight: 956.80

Molecular Formula: C45H44BrF2N9O8

Density: 1.54±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7c BPL-201517 NR-7c

CRBN

p38alpha

Inquiry

Molecular Weight: 970.83

Molecular Formula: C46H46BrF2N9O8

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7d BPL-201518 NR-7d 2550398-99-5

CRBN

p38alpha

Inquiry

Molecular Weight: 970.83

Molecular Formula: C46H46BrF2N9O8

Density: 1.52±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7e BPL-201519 NR-7e 2550397-82-3

CRBN

p38alpha

Inquiry

Molecular Weight: 970.83

Molecular Formula: C46H46BrF2N9O8

Density: 1.52±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7f BPL-201520 NR-7f 2550398-55-3

CRBN

p38alpha

Inquiry

Molecular Weight: 984.86

Molecular Formula: C47H48BrF2N9O8

Density: 1.51±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7g BPL-201521 NR-7g

CRBN

p38alpha

Inquiry

Molecular Weight: 984.86

Molecular Formula: C47H48BrF2N9O8

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7h BPL-201522 NR-7h 2550399-06-7

CRBN

p38alpha
p38beta

Inquiry

Molecular Weight: 998.88

Molecular Formula: C48H50BrF2N9O8

Density: 1.49±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α and p38β degradation.

NR-7i BPL-201523 NR-7i

CRBN

p38alpha

Inquiry

Molecular Weight: 1114.02

Molecular Formula: C53H59BrF2N10O10

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-7j BPL-201524 NR-7j

CRBN

p38alpha

Inquiry

Molecular Weight: 1050.36

Molecular Formula: C48H52BrClF2N10O8

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

GMB-805 BPL-201525 GMB-805 2489876-41-5

VHL

BCR-ABL

Inquiry

Molecular Weight: 894.39

Molecular Formula: C42H46ClF2N9O7S

Boiling Point: 1073.5±65.0°C at 760 Torr

Density: 1.404±0.06 g/cm3

Description: It is a BCR-ABL PROTAC whose in vivo activity can be enhanced by scaffold hopping.

26-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24-octaoxahexacosyl (3R)-3-(5-amino-4-carbamoyl-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate BPL-201526 26-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24-octaoxahexacosyl (3R)-3-(5-amino-4-carbamoyl-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 2250382-73-9

CRBN

BTK

Inquiry

Molecular Weight: 1109.15

Molecular Formula: C53H66F2N8O16

Boiling Point: 1114.5±65.0°C at 760 Torr

Density: 1.42±0.1 g/cm3

Description: It is a potent PROTAC that degrades BTK.

MZP-61 BPL-201527 MZP-61 2010159-49-4

VHL

BRD3
BRD4
BRD2

Inquiry

Molecular Weight: 992.64

Molecular Formula: C53H62ClN7O8S

Boiling Point: 1203.1±65.0°C at 760 Torr

Density: 1.283±0.06 g/cm3

Description: It is a selective degrader of BRD2, BRD3, and BRD4.

MZ4 BPL-201528 MZ4 2010159-46-1

VHL

BRD2
BRD3
BRD4

Inquiry

Molecular Weight: 958.61

Molecular Formula: C47H56ClN9O7S2

Density: 1.41±0.1 g/cm3

Description: It is a selective degrader of BRD2, BRD3, and BRD4.

BI-0319 BPL-201529 BI-0319 2341740-85-8

VHL

FAK

Inquiry

Molecular Weight: 1061.15

Molecular Formula: C52H59F3N8O11S

Density: 1.347±0.06 g/cm3

Description: It is a highly selective and functional PTK2 proteolysis-targeting chimera utilizing von Hippel-Lindau and cereblon ligand to hijack E3 ligase for PTK2 degradation.

LC-1 BPL-201530 LC-1 2502155-93-1

VHL

KRAS G12C

Inquiry

Molecular Weight: 1233.91

Molecular Formula: C63H78ClFN12O9S

Density: 1.296±0.06 g/cm3

Description: It is a VHL-recruiting PROTAC that targets the degradation of oncogenic KRASG12C.

LC-3 BPL-201531 LC-3 2502156-18-3

VHL

KRAS G12C

Inquiry

Molecular Weight: 1145.79

Molecular Formula: C59H70ClFN12O7S

Density: 1.312±0.06 g/cm3

Description: It is a VHL-recruiting PROTAC that targets the degradation of oncogenic KRASG12C.

LC-4 BPL-201532 LC-4 2502156-23-0

VHL

KRAS G12C

Inquiry

Molecular Weight: 1146.83

Molecular Formula: C60H73ClFN11O7S

Density: 1.289±0.06 g/cm3

Description: It is a VHL-recruiting PROTAC that targets the degradation of oncogenic KRASG12C.

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