PROTAC Library

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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
P22As BPL-201493 P22As 2635386-56-8

CRBN

BCR-ABL

Inquiry

Molecular Weight: 1061.49

Molecular Formula: C49H55ClF2N12O11

Density: 1.51±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL.

P10P BPL-201494 P10P 2512843-47-7

CRBN

BCR-ABL

Inquiry

Molecular Weight: 954.97

Molecular Formula: C49H45F3N12O6

Density: 1.48±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL.

P13P BPL-201495 P13P 2512846-42-1

CRBN

BCR-ABL

Inquiry

Molecular Weight: 999.02

Molecular Formula: C51H49F3N12O7

Density: 1.46±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL.

P16P BPL-201496 P16P 2512843-22-8

CRBN

BCR-ABL

Inquiry

Molecular Weight: 1043.08

Molecular Formula: C53H53F3N12O8

Density: 1.44±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL.

P19P BPL-201497 P19P 2512843-74-0

CRBN

BCR-ABL
BCR-ABL E255K
BCR-ABL H396R
BCR-ABL T315I
BCR-ABL V468F

Inquiry

Molecular Weight: 1087.13

Molecular Formula: C55H57F3N12O9

Density: 1.43±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL and drug-resistant mutant BCR-ABL E255K, BCR-ABL H396R, BCR-ABL T315I, and BCR-ABL V468F.

P22P BPL-201498 P22P 2512844-00-5

CRBN

BCR-ABL

Inquiry

Molecular Weight: 1131.18

Molecular Formula: C57H61F3N12O10

Density: 1.41±0.1 g/cm3

Description: It is a PROTAC that degrades BCR-ABL.

P22D1 BPL-201499 P22D1 2635386-60-4

CRBN

BCR-ABL T315I

Inquiry

Molecular Weight: 1005.17

Molecular Formula: C50H60N12O9S

Density: 1.41±0.1 g/cm3

Description: It is a PROTAC that degrades drug-resistant mutant BCR-ABL T315I.

BT1 BPL-201500 BT1 2694809-99-7

RNF114

BCR-ABL

Inquiry

Molecular Weight: 1187.81

Molecular Formula: C62H71ClN8O12S

Density: 1.40±0.1 g/cm3

Description: It is a nimbolide-based kinase degrader that preferentially degrades oncogenic BCR-ABL.

BT2 BPL-201501 BT2 2694810-00-7

RNF114

BCR-ABL

Inquiry

Molecular Weight: 1069.68

Molecular Formula: C57H61ClN8O9S

Density: 1.43±0.1 g/cm3

Description: It is a nimbolide-based kinase degrader that preferentially degrades oncogenic BCR-ABL.

NR-1a BPL-201502 NR-1a

CRBN

p38alpha

Inquiry

Molecular Weight: 790.62

Molecular Formula: C38H34BrF2N5O7

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-2a BPL-201503 NR-2a 2550398-79-1

CRBN

p38alpha

Inquiry

Molecular Weight: 818.63

Molecular Formula: C39H34BrF2N5O8

Boiling Point: 983.9±65.0°C at 760 Torr

Density: 1.58±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-1b BPL-201504 NR-1b 2550399-02-3

CRBN

p38alpha

Inquiry

Molecular Weight: 850.67

Molecular Formula: C40H38BrF2N5O9

Boiling Point: 985.5±65.0°C at 760 Torr

Density: 1.55±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-2b BPL-201505 NR-2b

CRBN

p38alpha

Inquiry

Molecular Weight: 878.68

Molecular Formula: C41H38BrF2N5O10

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-1c BPL-201506 NR-1c

CRBN

p38alpha

Inquiry

Molecular Weight: 1026.88

Molecular Formula: C48H54BrF2N5O13

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-3a BPL-201507 NR-3a 2550398-44-0

CRBN

p38alpha

Inquiry

Molecular Weight: 1017.88

Molecular Formula: C48H51BrF2N8O10

Density: 1.48±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-3b BPL-201508 NR-3b

CRBN

p38alpha

Inquiry

Molecular Weight: 1061.94

Molecular Formula: C50H55BrF2N8O11

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-3c BPL-201509 NR-3c 2550398-60-0

CRBN

p38alpha

Inquiry

Molecular Weight: 1058.94

Molecular Formula: C50H54BrF2N9O10

Density: 1.48±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-4 BPL-201510 NR-4

CRBN

p38alpha

Inquiry

Molecular Weight: 1086.94

Molecular Formula: C51H54BrF2N9O11

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-5a BPL-201511 NR-5a

CRBN

p38alpha

Inquiry

Molecular Weight: 1011.92

Molecular Formula: C50H53BrF2N8O8

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

NR-5b BPL-201512 NR-5b 2550398-96-2

CRBN

p38alpha

Inquiry

Molecular Weight: 997.90

Molecular Formula: C49H51BrF2N8O8

Density: 1.47±0.1 g/cm3

Description: It is a small molecule PROTAC that selectively targets p38α degradation.

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