Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201413	macroPROTAC-2		VHL	BRD2 BRD3 BRD4	Inquiry
Molecular Weight: 1074.72 Molecular Formula: C52H64ClN9O10S2 Description: It is a macrocyclic PROTAC by adding a cyclizing linker to the BET degrader MZ1. It enhances the degradation potency and selectivity between homologous targets.
	BPL-201414	MT-797	2231744-12-8	CRBN	BTK	Inquiry
Molecular Weight: 787.83 Molecular Formula: C41H41N9O8 Boiling Point: 1026.4±65.0°C at 760 Torr Density: 1.51±0.1 g/cm3 Description: It is a PROTAC that induces degradation of both wild-type and C481S mutant BTK.
	BPL-201415	JBJ-07-038	2140806-72-8	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 975.07 Molecular Formula: C50H51FN8O10S Density: 1.437±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201416	MT-783	2231744-26-4	CRBN	BTK	Inquiry
Molecular Weight: 743.78 Molecular Formula: C39H37N9O7 Boiling Point: 1008.6±65.0°C at 760 Torr Density: 1.54±0.1 g/cm3 Description: It is a PROTAC that induces degradation of both wild-type and C481S mutant BTK.
	BPL-201417	JBJ-07-200		CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 977.06 Molecular Formula: C50H50F2N8O9S Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201418	2-(6-(4-(4-(17-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-66-0	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 1056.17 Molecular Formula: C54H57N9O12S Density: 1.392±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201419	2-(6-(4-(4-(2-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-2-oxoethyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-67-1	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 952.06 Molecular Formula: C50H49N9O9S Density: 1.414±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201420	2-(6-(4-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-79-5	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 865.03 Molecular Formula: C48H48N8O6S Density: 1.387±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201421	2-(6-(4-(4-(8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-81-9	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 893.08 Molecular Formula: C50H52N8O6S Density: 1.359±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201422	2-(6-(4-(4-(3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-70-6	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 880.98 Molecular Formula: C47H44N8O8S Density: 1.450±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201423	2-(6-(4-(4-(3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-69-3	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 925.04 Molecular Formula: C49H48N8O9S Density: 1.430±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201424	2-(6-(4-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-71-7	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 1013.14 Molecular Formula: C53H56N8O11S Density: 1.396±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201425	2-(6-(4-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-64-8	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 1057.18 Molecular Formula: C55H60N8O12S Density: 1.382±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201426	2-(6-(4-(4-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-83-1	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 897.03 Molecular Formula: C48H48N8O8S Density: 1.409±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201427	2-(6-(6-(4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)pyridin-3-yl)-1-oxoisoindolin-2-yl)-2-(2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide	2140806-76-2	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 958.07 Molecular Formula: C49H51N9O10S Density: 1.435±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201428	2-(6-(6-(4-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethyl)piperazin-1-yl)pyridin-3-yl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide		CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 898.02 Molecular Formula: C47H47N9O8S Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201429	2-(6-(6-(4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)pyridin-3-yl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide		CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 942.07 Molecular Formula: C49H51N9O9S Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201430	2-(6-(6-(4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)pyridin-3-yl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide		CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 943.05 Molecular Formula: C49H50N8O10S Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201431	(2S,4R)-1-((2S)-3,3-Dimethyl-2-(3-(2-(2-(4-(5-(3-oxo-2-(2-oxo-1-phenyl-2-(thiazol-2-ylamino)ethyl)isoindolin-5-yl)pyridin-2-yl)piperazin-1-yl)ethoxy)ethoxy)propanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	EGFR L858R/T790M	Inquiry
Molecular Weight: 1083.35 Molecular Formula: C57H66N10O8S2 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201432	(2S,4R)-1-((14S)-14-(tert-Butyl)-12-oxo-1-(4-(5-(3-oxo-2-(2-oxo-1-phenyl-2-(thiazol-2-ylamino)ethyl)isoindolin-5-yl)pyridin-2-yl)piperazin-1-yl)-3,6,9-trioxa-13-azapentadecan-15-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	EGFR L858R/T790M	Inquiry
Molecular Weight: 1127.39 Molecular Formula: C59H70N10O9S2 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.

PROTAC Library