PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201273	RC-0h		CRBN	BTK	Inquiry
Molecular Weight: 1036.08 Molecular Formula: C52H53N13O11 Description: It is a reversible covalent BTK PROTAC. It shows enhanced inhibition of B cell activation compared to ibrutinib and exhibits potent degradation of BTK in patient-derived primary chronic lymphocytic leukemia cells.
	BPL-201274	RC-0i		CRBN	BTK	Inquiry
Molecular Weight: 992.02 Molecular Formula: C50H49N13O10 Description: It is a reversible covalent BTK PROTAC. It shows enhanced inhibition of B cell activation compared to ibrutinib and exhibits potent degradation of BTK in patient-derived primary chronic lymphocytic leukemia cells.
	BPL-201275	RC-0j		CRBN	BTK	Inquiry
Molecular Weight: 1168.23 Molecular Formula: C58H65N13O14 Description: It is a reversible covalent BTK PROTAC. It shows enhanced inhibition of B cell activation compared to ibrutinib and exhibits potent degradation of BTK in patient-derived primary chronic lymphocytic leukemia cells.
	BPL-201276	CCW 28-3	2361142-23-4	RNF4	BRD4	Inquiry
Molecular Weight: 821.83 Molecular Formula: C44H42Cl2N6O4S Density: 1.33±0.1 g/cm3 Description: CCW 28-3 is capable of degrading BRD4 in a proteasome- and RNF4-dependent manner.
	BPL-201277	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-78-9	CRBN	c-Met	Inquiry
Molecular Weight: 831.74 Molecular Formula: C40H36Cl2N6O8S Boiling Point: 1088.4±65.0°C at 760 Torr Density: 1.506±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201278	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-79-0	CRBN	c-Met	Inquiry
Molecular Weight: 845.76 Molecular Formula: C41H38Cl2N6O8S Boiling Point: 1089.9±65.0°C at 760 Torr Density: 1.487±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201279	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-80-3	CRBN	c-Met	Inquiry
Molecular Weight: 859.79 Molecular Formula: C42H40Cl2N6O8S Boiling Point: 1091.7±65.0°C at 760 Torr Density: 1.469±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201280	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-81-4	CRBN	c-Met	Inquiry
Molecular Weight: 847.73 Molecular Formula: C40H36Cl2N6O9S Boiling Point: 1097.4±65.0°C at 760 Torr Density: 1.517±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201281	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-82-5	CRBN	c-Met	Inquiry
Molecular Weight: 891.79 Molecular Formula: C42H40Cl2N6O10S Boiling Point: 1112.8±65.0°C at 760 Torr Density: 1.491±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201282	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)butyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-83-6	CRBN	c-Met	Inquiry
Molecular Weight: 831.74 Molecular Formula: C40H36Cl2N6O8S Boiling Point: 1094.4±65.0°C at 760 Torr Density: 1.506±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201283	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)pentyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-84-7	CRBN	c-Met	Inquiry
Molecular Weight: 845.76 Molecular Formula: C41H38Cl2N6O8S Boiling Point: 1095.7±65.0°C at 760 Torr Density: 1.487±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201284	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)hexyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-85-8	CRBN	c-Met	Inquiry
Molecular Weight: 859.79 Molecular Formula: C42H40Cl2N6O8S Boiling Point: 1097.4±65.0°C at 760 Torr Density: 1.469±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201285	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-86-9	CRBN	c-Met	Inquiry
Molecular Weight: 887.84 Molecular Formula: C44H44Cl2N6O8S Boiling Point: 1101.7±65.0°C at 760 Torr Density: 1.436±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201286	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-87-0	CRBN	c-Met	Inquiry
Molecular Weight: 847.73 Molecular Formula: C40H36Cl2N6O9S Boiling Point: 1103.4±65.0°C at 760 Torr Density: 1.517±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201287	(Z)-5-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-88-1	CRBN	c-Met	Inquiry
Molecular Weight: 891.79 Molecular Formula: C42H40Cl2N6O10S Boiling Point: 1118.5±65.0°C at 760 Torr Density: 1.491±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201288	(Z)-N-(4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-89-2	CRBN	c-KIT	Inquiry
Molecular Weight: 684.68 Molecular Formula: C35H33FN6O8 Boiling Point: 1003.2±65.0°C at 760 Torr Density: 1.446±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201289	(Z)-N-(8-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-90-5	CRBN	c-KIT	Inquiry
Molecular Weight: 740.79 Molecular Formula: C39H41FN6O8 Boiling Point: 1009.7±65.0°C at 760 Torr Density: 1.373±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201290	(Z)-N-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-91-6	CRBN	c-KIT	Inquiry
Molecular Weight: 816.84 Molecular Formula: C41H45FN6O11 Boiling Point: 1055.3±65.0°C at 760 Torr Density: 1.380±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201291	(Z)-N-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-92-7	CRBN	c-KIT	Inquiry
Molecular Weight: 654.69 Molecular Formula: C35H35FN6O6 Boiling Point: 920.2±65.0°C at 760 Torr Density: 1.414±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.
	BPL-201292	(Z)-N-(8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide	2222635-93-8	CRBN	c-KIT	Inquiry
Molecular Weight: 682.75 Molecular Formula: C37H39FN6O6 Boiling Point: 926.9±65.0°C at 760 Torr Density: 1.376±0.06 g/cm3 Description: It is a phenotypically relevant off-target of heterobifunctional phthalimide degrader.