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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
2-(2-((Cyclopropylmethyl)amino)pyridin-4-yl)-N-(1-(4-((2-(2-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)ethoxy)ethyl)carbamoyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)oxazole-4-carboxamide BPL-201333 2-(2-((Cyclopropylmethyl)amino)pyridin-4-yl)-N-(1-(4-((2-(2-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)ethoxy)ethyl)carbamoyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)oxazole-4-carboxamide 2360534-28-5

CRBN

IRAK4

 Inquiry

Molecular Weight: 897.87

Molecular Formula: C43H42F3N11O8

Density: 1.57±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201334 N-(3-Carbamoyl-1-(4-((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360534-46-7

CRBN

IRAK4

 Inquiry

Molecular Weight: 886.92

Molecular Formula: C45H46N10O10

Density: 1.52±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
2-(2-((Cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(4-((2-(2-(3-(3-(2,6-dioxopiperidin-3-yl)-2-oxo-2,3-dihydrobenzo[d]oxazol-7-yl)propoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)oxazole-4-carboxamide BPL-201335 2-(2-((Cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(4-((2-(2-(3-(3-(2,6-dioxopiperidin-3-yl)-2-oxo-2,3-dihydrobenzo[d]oxazol-7-yl)propoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)oxazole-4-carboxamide 2360535-53-9

CRBN

IRAK4

 Inquiry

Molecular Weight: 867.87

Molecular Formula: C43H43F2N9O9

Density: 1.53±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-(Difluoromethyl)-1-(4-((2-(2-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)piperidin-1-yl)ethoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201336 N-(3-(Difluoromethyl)-1-(4-((2-(2-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)piperidin-1-yl)ethoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360536-07-6

CRBN

IRAK4

 Inquiry

Molecular Weight: 991.93

Molecular Formula: C46H46F5N11O9

Density: 1.56±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-((((4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)morpholin-2-yl)methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201337 N-(3-Carbamoyl-1-(4-((((4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)morpholin-2-yl)methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360536-52-1

CRBN

IRAK4

 Inquiry

Molecular Weight: 942.91

Molecular Formula: C44H45F3N12O9

Density: 1.58±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-(((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201338 N-(3-Carbamoyl-1-(4-(((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360536-55-4

CRBN

IRAK4

 Inquiry

Molecular Weight: 872.94

Molecular Formula: C45H48N10O9

Density: 1.49±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-(((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(pyridin-4-yl)oxazole-4-carboxamide BPL-201339 N-(3-Carbamoyl-1-(4-(((2-(2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)propoxy)ethoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(pyridin-4-yl)oxazole-4-carboxamide 2360536-56-5

CRBN

IRAK4

 Inquiry

Molecular Weight: 803.83

Molecular Formula: C41H41N9O9

Density: 1.47±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-(((2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201340 N-(3-Carbamoyl-1-(4-(((2-(3-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propoxy)ethyl)(methyl)amino)methyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360536-60-1

CRBN

IRAK4

 Inquiry

Molecular Weight: 828.89

Molecular Formula: C43H44N10O8

Density: 1.51±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(6-((4-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide BPL-201341 N-(6-((4-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

CRBN

IRAK4

 Inquiry

Molecular Weight: 903.96

Molecular Formula: C46H52F3N7O9

Density: 1.46±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
N-(6-((4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide BPL-201342 N-(6-((4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

CRBN

IRAK4

 Inquiry

Molecular Weight: 948.01

Molecular Formula: C48H56F3N7O10

Density: 1.44±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
N-(6-((4-((1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide BPL-201343 N-(6-((4-((1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)methyl)-1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

CRBN

IRAK4

 Inquiry

Molecular Weight: 868.96

Molecular Formula: C46H51F3N8O6

Density: 1.49±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
N-(2-(1-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethyl)piperidin-4-yl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide BPL-201344 N-(2-(1-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethyl)piperidin-4-yl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide 2328212-69-5

CRBN

IRAK4

 Inquiry

Molecular Weight: 763.73

Molecular Formula: C37H36F3N7O8

Boiling Point: 876.7±65.0°C at 760 Torr

Density: 1.53±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
N-(2-(1-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oxy)ethoxy)ethyl)piperidin-4-yl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide BPL-201345 N-(2-(1-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)oxy)ethoxy)ethyl)piperidin-4-yl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide

CRBN

IRAK4

 Inquiry

Molecular Weight: 749.75

Molecular Formula: C37H38F3N7O7

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
N-(6-((4-((4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)cyclohexyl)methyl)piperazin-1-yl)methyl)-1-(4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide BPL-201346 N-(6-((4-((4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)cyclohexyl)methyl)piperazin-1-yl)methyl)-1-(4-(hydroxymethyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

CRBN

IRAK4

 Inquiry

Molecular Weight: 883.97

Molecular Formula: C47H52F3N7O7

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of neurodegenerative and cardiovascular diseases.
(2S,4R)-1-((S)-2-(2-(3-(2-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)ethoxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201347 (2S,4R)-1-((S)-2-(2-(3-(2-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)ethoxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2361114-77-2

VHL

ER

 Inquiry

Molecular Weight: 961.16

Molecular Formula: C51H63F3N6O7S

Boiling Point: 1027.3±65.0°C at 760 Torr

Density: 1.262±0.06 g/cm3

Description: It is a PROTAC that degrades estrogen receptor and is used for the treatment of cancer.
(2S,4R)-1-((S)-2-(tert-Butyl)-14-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201348 (2S,4R)-1-((S)-2-(tert-Butyl)-14-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2361114-90-9

VHL

ER

 Inquiry

Molecular Weight: 991.19

Molecular Formula: C52H65F3N6O8S

Boiling Point: 1039.4±65.0°C at 760 Torr

Density: 1.264±0.06 g/cm3

Description: It is a PROTAC that degrades estrogen receptor and is used for the treatment of cancer.
(2S,4R)-1-((S)-2-(2-(3-(3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)propoxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201349 (2S,4R)-1-((S)-2-(2-(3-(3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)propoxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2361115-35-5

VHL

ER

 Inquiry

Molecular Weight: 975.19

Molecular Formula: C52H65F3N6O7S

Boiling Point: 1029.5±65.0°C at 760 Torr

Density: 1.254±0.06 g/cm3

Description: It is a PROTAC that degrades estrogen receptor and is used for the treatment of cancer.
(2S,4R)-1-((S)-2-(2-(2-((5-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)-3,3-difluoropentyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201350 (2S,4R)-1-((S)-2-(2-(2-((5-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)-3,3-difluoropentyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2361115-86-6

VHL

ER

 Inquiry

Molecular Weight: 1025.19

Molecular Formula: C53H65F5N6O7S

Boiling Point: 1038.7±65.0°C at 760 Torr

Density: 1.273±0.06 g/cm3

Description: It is a PROTAC that degrades estrogen receptor and is used for the treatment of cancer.
(2S,4R)-1-((S)-2-(2-(2-((5-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)pentyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201351 (2S,4R)-1-((S)-2-(2-(2-((5-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)pentyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2361116-13-2

VHL

ER

 Inquiry

Molecular Weight: 1003.24

Molecular Formula: C54H69F3N6O7S

Boiling Point: 1036.8±65.0°C at 760 Torr

Density: 1.236±0.06 g/cm3

Description: It is a PROTAC that degrades estrogen receptor and is used for the treatment of cancer.
2-(6-(4-(4-(3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide BPL-201352 2-(6-(4-(4-(3-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide 2140806-63-7

CRBN

EGFR
EGFR L858R/T790M

 Inquiry

Molecular Weight: 969.09

Molecular Formula: C51H52N8O10S

Density: 1.412±0.06 g/cm3

Description: It is a PROTAC that degrades EGFR and EGFR L858R/T790M. It is used for the treatment of cancer and Alzheimer's disease.

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