Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201353	2-(6-(4-(4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-80-8	CRBN	EGFR L858R/T790M	Inquiry
Molecular Weight: 941.08 Molecular Formula: C50H52N8O9S Density: 1.392±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201354	2-(6-(4-(4-(14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide	2140806-82-0	CRBN	EGFR	Inquiry
Molecular Weight: 985.13 Molecular Formula: C52H56N8O10S Density: 1.377±0.06 g/cm3 Description: It is a PROTAC that degrades EGFR and is used for the treatment of cancer and Alzheimer's disease.
	BPL-201355	DDC-01-163	2140806-84-2	CRBN	EGFR L858R/T790M EGFR L858R/T790M/C797S EGFR L858R/T790M/L718Q	Inquiry
Molecular Weight: 942.07 Molecular Formula: C49H51N9O9S Density: 1.408±0.06 g/cm3 Description: It is a mutant-selective allosteric EGFR degrader that is effective against a broad range of drug-resistant mutations.
	BPL-201356	CZ40-53	2290504-90-2	CRBN	ALK	Inquiry
Molecular Weight: 1090.68 Molecular Formula: C53H68ClN9O12S Density: 1.328±0.06 g/cm3 Description: It is a PROTAC that targets protein degradation for the treatment of ALK-mediated cancers.
	BPL-201357	HC58-98	2351915-32-5	VHL	ALK	Inquiry
Molecular Weight: 1144.86 Molecular Formula: C57H74ClN9O10S2 Density: 1.293±0.06 g/cm3 Description: It is a PROTAC that targets protein degradation for the treatment of ALK-mediated cancers.
	BPL-201358	HC58-99	2351915-33-6	VHL	ALK	Inquiry
Molecular Weight: 1098.83 Molecular Formula: C56H72ClN9O8S2 Density: 1.283±0.06 g/cm3 Description: It is a PROTAC that targets protein degradation for the treatment of ALK-mediated cancers.
	BPL-201359	(2S,4R)-1-((2S)-21-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-2-(tert-butyl)-18-methyl-4,19-dioxo-6,9,12,15-tetraoxa-3,18-diazahenicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide	2378521-25-4	VHL	KRAS	Inquiry
Molecular Weight: 1223.87 Molecular Formula: C62H76ClFN10O11S Density: 1.318±0.06 g/cm3 Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201360	(2S,4R)-1-((2S)-24-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-2-(tert-butyl)-21-methyl-4,22-dioxo-6,9,12,15,18-pentaoxa-3,21-diazatetracosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide	2378255-46-8	VHL	KRAS	Inquiry
Molecular Weight: 1267.92 Molecular Formula: C64H80ClFN10O12S Density: 1.310±0.06 g/cm3 Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201361	3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-N-methylpropanamide	2378255-47-9	CRBN	KRAS	Inquiry
Molecular Weight: 994.48 Molecular Formula: C50H53ClFN9O10 Density: 1.419±0.06 g/cm3 Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201362	(2S,4R)-1-((2S)-19-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-2-(tert-butyl)-16-methyl-4,17-dioxo-7,10,13-trioxa-3,16-diazanonadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide		VHL	KRAS	Inquiry
Molecular Weight: 1193.84 Molecular Formula: C61H74ClFN10O10S Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201363	3-((6-Chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-propionylpiperazin-1-yl)quinazolin-2-yl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)oxy)-3,6,9,12-tetraoxatetradecyl)-N-methylpropanamide	2378255-54-8	CRBN	KRAS	Inquiry
Molecular Weight: 1027.55 Molecular Formula: C52H60ClFN8O11 Density: 1.364±0.06 g/cm3 Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201364	(2S,4R)-1-((2S)-2-(tert-Butyl)-21-((6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-propionylpiperazin-1-yl)quinazolin-2-yl)amino)-18-methyl-4,19-dioxo-6,9,12,15-tetraoxa-3,18-diazahenicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide	2378255-50-4	VHL	KRAS	Inquiry
Molecular Weight: 1225.88 Molecular Formula: C62H78ClFN10O11S Density: 1.313±0.06 g/cm3 Description: It is a PROTAC that mediates the degradation of KRAS protein for anticancer therapeutics.
	BPL-201365	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropyl)malonamide	2458219-46-8	VHL	SHP2	Inquiry
Molecular Weight: 948.62 Molecular Formula: C45H58ClN11O6S2 Boiling Point: 1202.6±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201366	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(4-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutyl)malonamide	2458219-47-9	VHL	SHP2	Inquiry
Molecular Weight: 962.64 Molecular Formula: C46H60ClN11O6S2 Boiling Point: 1207.4±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201367	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)malonamide	2458219-48-0	VHL	SHP2	Inquiry
Molecular Weight: 976.67 Molecular Formula: C47H62ClN11O6S2 Boiling Point: 1211.3±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201368	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(6-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexyl)malonamide	2458219-49-1	VHL	SHP2	Inquiry
Molecular Weight: 990.68 Molecular Formula: C48H64ClN11O6S2 Boiling Point: 1213.5±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201369	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)malonamide	2458219-50-4	VHL	SHP2	Inquiry
Molecular Weight: 1004.72 Molecular Formula: C49H66ClN11O6S2 Boiling Point: 1216.0±65.0°C at 760 Torr Density: 1.36±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201370	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(8-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctyl)malonamide	2458219-51-5	VHL	SHP2	Inquiry
Molecular Weight: 1018.75 Molecular Formula: C50H68ClN11O6S2 Boiling Point: 1218.6±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201371	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(9-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-9-oxononyl)malonamide	2458219-52-6	VHL	SHP2	Inquiry
Molecular Weight: 1032.78 Molecular Formula: C51H70ClN11O6S2 Boiling Point: 1221.3±65.0°C at 760 Torr Density: 1.34±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.
	BPL-201372	N1-(3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(10-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-10-oxodecyl)malonamide	2458219-53-7	VHL	SHP2	Inquiry
Molecular Weight: 1046.81 Molecular Formula: C52H72ClN11O6S2 Boiling Point: 1218.8±65.0°C at 760 Torr Density: 1.33±0.1 g/cm3 Description: It is a potent and effective PROTAC degrader of SHP2 protein.

PROTAC Library