PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201233	4-((2-(2-(2-(4-((5-Chloro-4-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)phenoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	IGF-1R Src	Inquiry
Molecular Weight: 704.14 Molecular Formula: C33H34ClN9O7 Description: It is a proteolysis targeting chimera (PROTAC) for the dual degradation of IGF-1R and Src.
	BPL-201234	4-((2-(2-(4-((3-(4-Amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)amino)phenoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	IGF-1R Src	Inquiry
Molecular Weight: 738.21 Molecular Formula: C37H36ClN9O6 Description: It is a proteolysis targeting chimera (PROTAC) for the dual degradation of IGF-1R and Src.
	BPL-201235	4-((2-(2-(2-(4-((3-(4-Amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)amino)phenoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	IGF-1R Src	Inquiry
Molecular Weight: 782.26 Molecular Formula: C39H40ClN9O7 Description: It is a proteolysis targeting chimera (PROTAC) for the dual degradation of IGF-1R and Src.
	BPL-201236	4-((2-(2-(4-(((1-(3-(4-Amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)phenoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	IGF-1R Src	Inquiry
Molecular Weight: 819.28 Molecular Formula: C40H39ClN12O6 Description: It is a proteolysis targeting chimera (PROTAC) for the dual degradation of IGF-1R and Src.
	BPL-201237	4-((2-(2-(2-(4-(((1-(3-(4-Amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)phenoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	IGF-1R Src	Inquiry
Molecular Weight: 863.34 Molecular Formula: C42H43ClN12O7 Description: It is a proteolysis targeting chimera (PROTAC) for the dual degradation of IGF-1R and Src.
	BPL-201238	DGY-03-081	2414414-23-4	CRBN	NS3	Inquiry
Molecular Weight: 1064.28 Molecular Formula: C56H77N11O10 Density: 1.33±0.1 g/cm3 Description: It is a small molecular degrader of hepatitis C virus protease that reduces susceptibility to resistance mutations.
	BPL-201239	DGY-04-035	2414414-35-8	CRBN	NS3	Inquiry
Molecular Weight: 1110.28 Molecular Formula: C56H75N11O13 Density: 1.37±0.1 g/cm3 Description: It is a small molecular degrader of hepatitis C virus protease that reduces susceptibility to resistance mutations.
	BPL-201240	DGY-08-097	2414414-50-7	CRBN	NS3	Inquiry
Molecular Weight: 1161.32 Molecular Formula: C60H76N10O14 Density: 1.38±0.1 g/cm3 Description: It is a small molecular degrader of hepatitis C virus protease that reduces susceptibility to resistance mutations.
	BPL-201241	PZ15227	2143464-25-7	CRBN	BCL-xL	Inquiry
Molecular Weight: 1484.16 Molecular Formula: C71H82ClF3N12O12S3 Density: 1.44±0.1 g/cm3 Description: It is a Bcl-xl PROTAC that targets Bcl-xl to cereblon (CRBN) E3 ligase for degradation.
	BPL-201242	2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxoethoxy)ethoxy)ethyl (2S,4S)-1-acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-2-carboxylate	2743379-99-7	CRBN	BTK	Inquiry
Molecular Weight: 871.86 Molecular Formula: C44H41N9O11 Boiling Point: 1137.2±65.0°C at 760 Torr Density: 1.53±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201243	2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxoethoxy)ethoxy)ethoxy)ethyl (2S,4S)-1-acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-2-carboxylate	2743380-02-9	CRBN	BTK	Inquiry
Molecular Weight: 915.92 Molecular Formula: C46H45N9O12 Boiling Point: 1152.0±65.0°C at 760 Torr Density: 1.50±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201244	14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-14-oxo-3,6,9,12-tetraoxatetradecyl (2S,4S)-1-acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-2-carboxylate	2743380-00-7	CRBN	BTK	Inquiry
Molecular Weight: 959.97 Molecular Formula: C48H49N9O13 Boiling Point: 1167.3±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201245	17-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-17-oxo-3,6,9,12,15-pentaoxaheptadecyl (2S,4S)-1-acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-2-carboxylate	2743380-01-8	CRBN	BTK	Inquiry
Molecular Weight: 1004.02 Molecular Formula: C50H53N9O14 Boiling Point: 1179.8±65.0°C at 760 Torr Density: 1.46±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201246	(2S,4S)-1-Acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)pyrrolidine-2-carboxamide	2743380-03-0	CRBN	BTK	Inquiry
Molecular Weight: 796.85 Molecular Formula: C42H40N10O7 Boiling Point: 1132.8±65.0°C at 760 Torr Density: 1.51±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201247	(2S,4S)-1-Acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)pyrrolidine-2-carboxamide	2743380-04-1	CRBN	BTK	Inquiry
Molecular Weight: 824.88 Molecular Formula: C44H44N10O7 Boiling Point: 1133.9±65.0°C at 760 Torr Density: 1.48±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201248	(2S,4S)-1-Acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)pyrrolidine-2-carboxamide	2743380-05-2	CRBN	BTK	Inquiry
Molecular Weight: 852.95 Molecular Formula: C46H48N10O7 Boiling Point: 1136.5±65.0°C at 760 Torr Density: 1.44±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201249	(2S,4S)-1-Acryloyl-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)dodecyl)pyrrolidine-2-carboxamide	2743380-06-3	CRBN	BTK	Inquiry
Molecular Weight: 909.06 Molecular Formula: C50H56N10O7 Boiling Point: 1132.6±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201250	2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxoethoxy)ethoxy)ethyl (4S)-4-acrylamido-5-((3-((5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-yl)amino)phenyl)amino)-5-oxopentanoate	2743380-07-4	CRBN	BTK	Inquiry
Molecular Weight: 1091.03 Molecular Formula: C53H49F3N10O13 Density: 1.471±0.06 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201251	14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-14-oxo-3,6,9,12-tetraoxatetradecyl (4S)-4-acrylamido-5-((3-((5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-yl)amino)phenyl)amino)-5-oxopentanoate	2743380-08-5	CRBN	BTK	Inquiry
Molecular Weight: 1179.13 Molecular Formula: C57H57F3N10O15 Density: 1.437±0.06 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.
	BPL-201252	(2S)-2-Acrylamido-N5-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-N1-(3-((5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-yl)amino)phenyl)pentanediamide	2743380-09-6	CRBN	BTK	Inquiry
Molecular Weight: 1016.01 Molecular Formula: C51H48F3N11O9 Density: 1.449±0.06 g/cm3 Description: It is a covalent inhibitor-based chimeric degrader used to degrade BTK and BLK kinases.