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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(2S,4R)-1-((S)-2-(2-(2-(4'-(((1r,3r)-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)-[1,1'-biphenyl]-4-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201313 (2S,4R)-1-((S)-2-(2-(2-(4'-(((1r,3r)-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)-[1,1'-biphenyl]-4-yl)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

VHL

AR

 Inquiry

Molecular Weight: 973.64

Molecular Formula: C54H61ClN6O7S

Description: It is a PROTAC-androgen receptor degrader used in the treatment of prostate cancer and Kennedy's disease.
4-((2-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methyloxazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)phenyl ((1r,3S)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamate BPL-201314 4-((2-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methyloxazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)phenyl ((1r,3S)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamate

VHL

AR

 Inquiry

Molecular Weight: 883.44

Molecular Formula: C47H55ClN6O9

Description: It is a PROTAC-androgen receptor degrader used in the treatment of prostate cancer and Kennedy's disease.
N-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-201315 N-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267290-95-7

CRBN

Tau

 Inquiry

Molecular Weight: 582.62

Molecular Formula: C31H30N6O6

Boiling Point: 970.8±65.0°C at 760 Torr

Density: 1.445±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cell derived neuronal models of tauopathy.
N-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-201316 N-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267290-97-9

CRBN

Tau

 Inquiry

Molecular Weight: 670.72

Molecular Formula: C35H38N6O8

Boiling Point: 986.2±65.0°C at 760 Torr

Density: 1.392±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cell derived neuronal models of tauopathy.
N-(17-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide BPL-201317 N-(17-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide 2267290-98-0

CRBN

Tau

 Inquiry

Molecular Weight: 758.83

Molecular Formula: C39H46N6O10

Boiling Point: 1009.3±65.0°C at 760 Torr

Density: 1.353±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cell derived neuronal models of tauopathy.
(2S,4R)-1-((S)-2-(tert-Butyl)-4,17-dioxo-19-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13-trioxa-3,16-diazanonadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201318 (2S,4R)-1-((S)-2-(tert-Butyl)-4,17-dioxo-19-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13-trioxa-3,16-diazanonadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-02-9

VHL

Tau

 Inquiry

Molecular Weight: 870.09

Molecular Formula: C46H59N7O8S

Boiling Point: 1133.1±65.0°C at 760 Torr

Density: 1.267±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cell derived neuronal models of tauopathy.
(2S,4R)-1-((S)-2-(tert-Butyl)-4,23-dioxo-25-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16,19-pentaoxa-3,22-diazapentacosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201319 (2S,4R)-1-((S)-2-(tert-Butyl)-4,23-dioxo-25-(5H-pyrido[4,3-b]indol-7-yl)-7,10,13,16,19-pentaoxa-3,22-diazapentacosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2267291-55-2

VHL

Tau

 Inquiry

Molecular Weight: 958.19

Molecular Formula: C50H67N7O10S

Boiling Point: 1164.8±65.0°C at 760 Torr

Density: 1.252±0.06 g/cm3

Description: It is a Tau-targeted protein degrader enabled by patient-induced pluripotent stem cell derived neuronal models of tauopathy.
Degronimer 1 BPL-201320 Degronimer 1 2259851-83-5

CRBN

BRD4

 Inquiry

Molecular Weight: 798.46

Molecular Formula: C42H52ClN9O3S

Density: 1.37±0.1 g/cm3

Description: It is a PROTAC molecule for the treatment of autoimmune disorders.
Degronimer 2 BPL-201321 Degronimer 2 2259851-84-6

CRBN

BRD4

 Inquiry

Molecular Weight: 771.37

Molecular Formula: C43H47ClN10O2

Density: 1.41±0.1 g/cm3

Description: It is a PROTAC molecule for the treatment of autoimmune disorders.
N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[5-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]pentyl]oxy]benzamide BPL-201322 N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[5-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]pentyl]oxy]benzamide 1818885-25-4

CRBN

AR

 Inquiry

Molecular Weight: 798.34

Molecular Formula: C43H48ClN5O8

Boiling Point: 973.8±65.0°C at 760 Torr

Density: 1.34±0.1 g/cm3

Description: It is a PROTAC that degrades AR and is used to treat hyperplasia and cancer.
4-(3-(4'-((5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile BPL-201323 4-(3-(4'-((5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)oxy)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 1818885-27-6

CRBN

AR

 Inquiry

Molecular Weight: 822.87

Molecular Formula: C43H37F3N6O6S

Density: 1.48±0.1 g/cm3

Description: It is a PROTAC that degrades AR and is used to treat hyperplasia and cancer.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-((14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)phenyl)acetamide BPL-201324 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-((14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)phenyl)acetamide 1818885-29-8

CRBN

BRD4

 Inquiry

Molecular Weight: 967.49

Molecular Formula: C48H51ClN8O10S

Density: 1.45±0.1 g/cm3

Description: It is a PROTAC that degrades Bromodomain and is used to treat hyperplasia and cancer.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)phenyl)acetamide BPL-201325 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)phenyl)acetamide 1818885-30-1

CRBN

BRD4

 Inquiry

Molecular Weight: 879.38

Molecular Formula: C44H43ClN8O8S

Density: 1.49±0.1 g/cm3

Description: It is a PROTAC that degrades Bromodomain and is used to treat hyperplasia and cancer.
N-(3-((5-Bromo-2-((4-((17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)oxy)phenyl)amino)pyrimidin-4-yl)amino)propyl)-N-methylcyclobutanecarboxamide BPL-201326 N-(3-((5-Bromo-2-((4-((17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)oxy)phenyl)amino)pyrimidin-4-yl)amino)propyl)-N-methylcyclobutanecarboxamide 1883863-26-0

CRBN

TBK1

 Inquiry

Molecular Weight: 953.89

Molecular Formula: C44H57BrN8O11

Density: 1.413±0.06 g/cm3

Description: It is a PROTAC that degrades TBK1 and is used to treat hyperplasia and cancer.
N-(3-((5-Bromo-2-((4-((14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)phenyl)amino)pyrimidin-4-yl)amino)propyl)-N-methylcyclobutanecarboxamide BPL-201327 N-(3-((5-Bromo-2-((4-((14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)phenyl)amino)pyrimidin-4-yl)amino)propyl)-N-methylcyclobutanecarboxamide 1818885-33-4

CRBN

TBK1

 Inquiry

Molecular Weight: 909.84

Molecular Formula: C42H53BrN8O10

Density: 1.431±0.06 g/cm3

Description: It is a PROTAC that degrades TBK1 and is used to treat hyperplasia and cancer.
(Z)-4-(4-((3-(3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)-2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile BPL-201328 (Z)-4-(4-((3-(3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)-2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile 1818885-35-6

CRBN

ERRalpha

 Inquiry

Molecular Weight: 777.73

Molecular Formula: C37H30F3N5O9S

Density: 1.55±0.1 g/cm3

Description: It is a PROTAC that degrades ERRalpha and is used to treat hyperplasia and cancer.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1S)-1-(4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)phenyl)ethyl)acetamide BPL-201329 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1S)-1-(4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)phenyl)ethyl)acetamide 1818885-40-3

CRBN

BRD4

 Inquiry

Molecular Weight: 863.40

Molecular Formula: C44H43ClN8O7S

Density: 1.48±0.1 g/cm3

Description: It is a PROTAC that degrades Bromodomain and is used to treat hyperplasia and cancer.
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)acetamide BPL-201330 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)acetamide 1818885-41-4

CRBN

BRD4

 Inquiry

Molecular Weight: 743.25

Molecular Formula: C36H35ClN8O6S

Density: 1.56±0.1 g/cm3

Description: It is a PROTAC that degrades Bromodomain and is used to treat hyperplasia and cancer.
N-(3-(Aminomethyl)-1-(4-((2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201331 N-(3-(Aminomethyl)-1-(4-((2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360534-08-1

CRBN

IRAK4

 Inquiry

Molecular Weight: 887.83

Molecular Formula: C41H40F3N11O9

Density: 1.57±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.
N-(3-Carbamoyl-1-(4-(((1-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)piperidin-2-yl)methyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide BPL-201332 N-(3-Carbamoyl-1-(4-(((1-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)piperidin-2-yl)methyl)carbamoyl)phenyl)-1H-pyrazol-4-yl)-2-(2-((2,2,2-trifluoroethyl)amino)pyridin-4-yl)oxazole-4-carboxamide 2360534-16-1

CRBN

IRAK4

 Inquiry

Molecular Weight: 954.92

Molecular Formula: C45H45F3N12O9

Density: 1.59±0.1 g/cm3

Description: It is a PROTAC that degrades IRAK4 and is used for the treatment of cancer.

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