PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201153	1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)piperidine-2-carboxamide	2447066-39-7	CRBN	PD-L1	Inquiry
Molecular Weight: 937.45 Molecular Formula: C52H49ClN6O9 Density: 1.44±0.1 g/cm3 Description: It is a resorcinol diphenyl ether-based PROTAC-like molecule as a dual inhibitor and degrader of PD-L1.
	BPL-201154	1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)piperidine-2-carboxamide	2447066-40-0	CRBN	PD-L1	Inquiry
Molecular Weight: 951.48 Molecular Formula: C53H51ClN6O9 Density: 1.43±0.1 g/cm3 Description: It is a resorcinol diphenyl ether-based PROTAC-like molecule as a dual inhibitor and degrader of PD-L1.
	BPL-201155	1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)piperidine-2-carboxamide	2447066-41-1	CRBN	PD-L1	Inquiry
Molecular Weight: 965.50 Molecular Formula: C54H53ClN6O9 Density: 1.41±0.1 g/cm3 Description: It is a resorcinol diphenyl ether-based PROTAC-like molecule as a dual inhibitor and degrader of PD-L1.
	BPL-201156	1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)piperidine-2-carboxamide	2447066-42-2	CRBN	PD-L1	Inquiry
Molecular Weight: 979.53 Molecular Formula: C55H55ClN6O9 Density: 1.40±0.1 g/cm3 Description: It is a resorcinol diphenyl ether-based PROTAC-like molecule as a dual inhibitor and degrader of PD-L1.
	BPL-201157	1-(5-Chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)piperidine-2-carboxamide	2447066-43-3	CRBN	PD-L1	Inquiry
Molecular Weight: 993.56 Molecular Formula: C56H57ClN6O9 Density: 1.39±0.1 g/cm3 Description: It is a resorcinol diphenyl ether-based PROTAC-like molecule as a dual inhibitor and degrader of PD-L1.
	BPL-201158	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(4-(4-((2-(2-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)butanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1709.56 Molecular Formula: C84H105ClF3N13O12S4 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201159	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(4-(4-((2-(2-(2-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)butanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1753.61 Molecular Formula: C86H109ClF3N13O13S4 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201160	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(2-(2-(2-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)acetyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1600.43 Molecular Formula: C79H98ClF3N10O12S4 Density: 1.40±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201161	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(14-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)-3,6,9,12-tetraoxatetradecanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1688.53 Molecular Formula: C83H106ClF3N10O14S4 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201162	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(4-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)butanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1540.37 Molecular Formula: C77H94ClF3N10O10S4 Density: 1.40±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201163	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(5-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)pentanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1554.37 Molecular Formula: C78H96ClF3N10O10S4 Density: 1.39±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201164	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(6-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)hexanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1568.43 Molecular Formula: C79H98ClF3N10O10S4 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201165	4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-(((R)-4-(4-(7-(3-(2-((S)-1-((R)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)heptanoyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide		cIAP1	BCL-xL	Inquiry
Molecular Weight: 1582.45 Molecular Formula: C80H100ClF3N10O10S4 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201166	(4S,7S,9aS)-N-((R)-6-(2-(2-((1-(4-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)ethoxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1683.49 Molecular Formula: C83H107ClF3N13O13S3 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201167	(4S,7S,9aS)-N-((R)-6-(2-(2-(2-((1-(4-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)ethoxy)ethoxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1727.55 Molecular Formula: C85H111ClF3N13O14S3 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201168	(4S,7S,9aS)-N-((R)-6-(2-(2-(2-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1574.36 Molecular Formula: C78H100ClF3N10O13S3 Density: 1.39±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201169	(4S,7S,9aS)-N-((R)-6-((14-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-14-oxo-3,6,9,12-tetraoxatetradecyl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1662.47 Molecular Formula: C82H108ClF3N10O15S3 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201170	(4S,7S,9aS)-N-((R)-6-((5-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-5-oxopentyl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1528.34 Molecular Formula: C77H98ClF3N10O11S3 Density: 1.39±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201171	(4S,7S,9aS)-N-((R)-6-((6-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-6-oxohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1542.36 Molecular Formula: C78H100ClF3N10O11S3 Density: 1.38±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.
	BPL-201172	(4S,7S,9aS)-N-((R)-6-((7-(4-((R)-3-((4-(N-(4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptyl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8,8-dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxooctahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide		XIAP	BCL-xL	Inquiry
Molecular Weight: 1556.39 Molecular Formula: C79H102ClF3N10O11S3 Density: 1.37±0.1 g/cm3 Description: It is an IAP-recruiting BCL-XL PROTAC as a potent degrader across multiple cancer cell lines.