Acid-PEG9-NHS ester
CAS No.: 1895916-27-4
Cat No.: BP-500446
Purity: ≥95%
4.5 
Acid-PEG9-NHS ester is an NHS-activated polyethylene glycol (PEG) linker designed for efficient, covalent conjugation to primary amines on PROTAC components and other targeting ligands. Structurally, it comprises a carboxyl-terminated PEG chain of moderate length bearing an N-hydroxysuccinimide (NHS) ester at one end, enabling stable amide bond formation under standard bioconjugation conditions while preserving the PEG’s hydrophilic, flexible spacer properties. In PROTAC design, this linker functions as a modular “bridge” that can connect an amine-bearing ligand (e.g., a warhead or E3 ligase binder) to a second molecular element, improving effective reach and reducing steric constraints that can otherwise impair ternary complex formation. Its PEG spacer can also enhance aqueous solubility and mitigate nonspecific hydrophobic interactions, supporting more reproducible synthesis and characterization of targeted protein degradation constructs.
Structure of 1895916-27-4
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Acid-PEG9-NHS ester is a PEG-based linker designed for efficient conjugation of targeting ligands in PROTAC construction. Its NHS-ester functionality enables robust amide-bond formation with primary amines, while the PEG spacer supports favorable solubility and conformational flexibility for bioconjugation workflows. The linker is widely used to connect small-molecule ligands to protein-binding modules, improving practical coupling efficiency in targeted protein degradation research. Detailed structural and reactivity considerations are provided below.
Structure: This linker contains a polyethylene glycol segment terminated by a carboxylic acid and an N-hydroxysuccinimide ester. The NHS ester is an activated carbonate-like acylating group, while the PEG chain provides ether-rich, flexible connectivity that enhances aqueous compatibility and reduces steric constraints during coupling.
Reactivity: The NHS ester reacts with primary amines to form stable amide bonds via nucleophilic acyl substitution. Typical coupling is performed under mildly basic aqueous buffer conditions to maintain amine nucleophilicity while preserving NHS-ester reactivity. Common solvents include water or aqueous alcohol mixtures, and catalysts are generally not required beyond pH control. After coupling, unreacted NHS ester is quenched or removed to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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