Amino-PEG3-C2-sulfonic acid
CAS No.: 1817735-43-5
Cat No.: BP-501406
4.5 
Amino-PEG3-C2-sulfonic acid is a heterobifunctional PEG-based linker featuring a terminal amino group for covalent attachment to a ligand (e.g., an E3 ligase binder or target-binding moiety) and a short PEG3 chain that provides conformational flexibility and aqueous solubility. The C2-sulfonic acid terminus is strongly anionic at physiological pH and mainly contributes charge and water solubility, while the primary amine is the main direct coupling handle. In PROTAC design, such PEG–sulfonate linkers act as spacing elements that tune the effective distance and relative orientation between the two binding domains, which can strongly influence formation of the ternary complex and subsequent ubiquitination-driven degradation. This linker’s combination of a reactive amino handle and a charged sulfonate makes it useful for constructing modular, water-compatible PROTACs and for systematic optimization of linker length and polarity to enhance degradation potency and reduce nonspecific interactions.
Structure of 1817735-43-5
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker building block designed to provide aqueous compatibility, conformational flexibility, and a robust functional handle for conjugation to targeting ligands and E3-recruiting moieties. Its sulfonic acid functionality supports strong ionic interactions and can help tune solubility and effective presentation of the two binding partners in targeted protein degradation workflows. The structure and reactivity considerations for constructing PROTACs using this linker are described in detail below.
Structure: The linker contains a short polyethylene glycol segment providing hydrophilicity and flexible ether linkages, coupled to an amino group for chemical attachment. A sulfonic acid group introduces a strongly polar, ionizable functionality, enabling salt formation and stabilizing aqueous behavior. Overall, it presents multiple heteroatoms that support hydrogen bonding and solvation.
Reactivity: The amino group is suitable for standard amide or urea-forming coupling reactions with activated carboxylic acids or isocyanates, enabling conjugation to ligand scaffolds. The sulfonic acid group is typically maintained under mild conditions and can be used to modulate ionic character rather than as a primary reactive site. Common approaches use carbodiimide or activated ester chemistry in polar organic/aqueous mixtures, with bases to promote nucleophilic coupling while preserving PEG integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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