Amino-PEG36-acid
CAS No.: 2241751-76-6
Cat No.: BP-501556
4.5 
Amino-PEG36-acid is a polyethylene glycol (PEG)–based linker bearing a terminal primary amine and a carboxylic acid, providing a flexible, hydrophilic chain suitable for modular PROTAC construction. Structurally, it consists of an extended PEG segment that acts as a spacer to tune the effective distance and conformational freedom between a ligand that recruits an E3 ubiquitin ligase and a ligand that binds the target protein. The terminal functional groups enable straightforward conjugation chemistry: the amine can be used to form amide or other coupling linkages with activated carboxylates on PROTAC partners, while the carboxyl group can be leveraged for coupling to complementary amines or for further derivatization. In targeted protein degradation research, such PEG linkers are widely used to mitigate steric clashes, improve aqueous solubility, and help optimize ternary complex formation, thereby supporting systematic structure–activity studies. This linker is valuable for researchers seeking reproducible, tunable spacing in PROTAC designs and for generating degraders with improved handling and conjugation flexibility.
Structure of 2241751-76-6
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Amino-PEG36-acid is a polyethylene glycol-based PROTAC linker designed to provide a flexible, hydrophilic spacer between an E3 ligase ligand and a target-binding warhead. Its ether-rich backbone and terminal functional group enable robust conjugation strategies commonly used in targeted protein degradation workflows. The linker’s conformational flexibility and solubility advantages can help tune effective distance and reduce steric constraints, supporting efficient formation of ternary complexes. Detailed structural and synthetic considerations are provided below.
Structure: Amino-PEG36-acid contains a PEG chain composed of repeating ether units, offering high polarity and conformational flexibility. It bears an amino functionality and a terminal carboxylic acid, enabling formation of amide or related linkages. The molecule is dominated by C–O ether bonds and stable carbon–carbon connectivity along the polymer backbone.
Reactivity: The carboxylic acid can be activated for coupling to amines or other nucleophiles using standard peptide-coupling chemistries (for example, carbodiimide-based activation with an appropriate additive, or acid-activated ester routes). The amino group can serve as a nucleophile for amide bond formation or for further functionalization. Typical conditions employ polar aprotic solvents and mild bases to preserve sensitive ligands, following established PROTAC linker-conjugation principles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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