Amino-PEG6-amine
CAS No.: 76927-70-3
Cat No.: BP-501500
Purity: >97%
4.5 
Amino-PEG6-amine is a bifunctional polyethylene glycol linker featuring terminal primary amines separated by a six-unit PEG chain, providing a flexible, hydrophilic spacer with minimal intrinsic reactivity. In PROTAC and related targeted protein degradation constructs, this type of linker is used to connect two functional modules—typically a ligand for an E3 ubiquitin ligase and a ligand or binding moiety for the target protein—while maintaining sufficient conformational freedom to promote productive ternary complex formation. The PEG segment can reduce nonspecific hydrophobic interactions, improve aqueous solubility, and help tune the effective distance and orientation between the recruited proteins, which are critical determinants of ubiquitination efficiency and cellular degradation potency. As a versatile, chemically addressable spacer, Amino-PEG6-amine is valuable for systematic linker optimization, including exploring how linker length and flexibility influence degradation profiles across different target–E3 pairings.
Structure of 76927-70-3
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Amino-PEG6-amine is a flexible poly(ethylene glycol) linker designed for modular assembly of PROTACs, enabling controlled spatial separation between a target-binding ligand and an E3 ligase recruiter. Its ether-rich backbone provides conformational mobility and improved solubility, which can support productive ternary complex formation. The linker is commonly used in linker-functionalization workflows where amine handles facilitate reliable conjugation chemistry. The detailed structural and reactivity considerations are provided below.
Structure: Amino-PEG6-amine contains a PEG-based, ether-rich chain bearing terminal primary amines. The linker features repeating ethylene oxide units connected through ether oxygen atoms, with C–N bonds at the termini. This architecture yields a highly polar, hydrophilic, and conformationally flexible scaffold suitable for bioconjugation.
Reactivity: The terminal primary amines enable standard PROTAC linker coupling strategies, including amide-bond formation via activated carboxylic acids or acyl chlorides, and urea/amide formation using carbodiimide or isocyanate-type intermediates. Typical conditions use polar aprotic or buffered aqueous/organic solvent systems, with base to promote nucleophilic substitution. Reaction monitoring by chromatographic or spectrometric methods is recommended to ensure controlled coupling and minimize side reactions such as over-acylation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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