Azido-PEG6-alcohol
CAS No.: 86770-69-6
Cat No.: BP-501173
Purity: >98.0%
4.5 
Azido-PEG6-alcohol is a polyethylene glycol (PEG) linker bearing a terminal azide functional group and a primary alcohol at the opposite end. The PEG segment provides a flexible, hydrophilic spacer that can reduce steric interference between a PROTAC’s targeting ligand and its E3 ligase–recruiting moiety, while the azide enables bioorthogonal conjugation via copper-free or copper-catalyzed azide–alkyne cycloaddition (click chemistry) to attach compatible partners. In targeted protein degradation workflows, this linker is commonly used to modularly connect two building blocks under mild conditions, allowing researchers to tune linker length and physicochemical properties to optimize ternary complex formation and degradation potency. Its alcohol terminus can also serve as a handle for further derivatization, facilitating systematic structure–activity studies. Overall, Azido-PEG6-alcohol is a practical, widely used PEG-based conjugation reagent for constructing and optimizing PROTACs and related targeted degraders.
Structure of 86770-69-6
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This Azido-PEG6-alcohol linker is engineered for PROTAC assembly, providing a flexible polyethylene glycol spacer terminating in a reactive azide group and a hydroxyl handle for downstream functionalization. Its ether-rich, hydrophilic character supports solubility and conformational adaptability in targeted protein degradation constructs. The azide functionality enables widely used conjugation strategies compatible with modular PROTAC design; detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a polyethylene glycol chain featuring repeating ether linkages, capped by an azide substituent and a terminal alcohol. It contains an organic azide group and oxygen-rich functional sites, with a flexible, hydrogen-bonding-capable backbone that promotes aqueous compatibility and adaptable spacing.
Reactivity: The azide group is suitable for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling efficient “click” conjugation to alkyne-bearing ligands under mild conditions. The terminal alcohol can be converted to activated derivatives (for example, esters or carbonates) for coupling to carboxylate or amine partners. Typical reactions use polar aprotic or aqueous-organic solvents with inert atmosphere when required for azide stability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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