Azide-PEG3-C1-Ala
CAS No.: 2054345-67-2
Cat No.: BP-500613
4.5 
Azide-PEG3-C1-Ala is a PEG-based, azide-terminated linker bearing a short three–ethylene glycol spacer and a C1 functional handle suitable for coupling to amino-acid derived motifs, here exemplified by an alanine (Ala) unit. The azide group enables efficient bioorthogonal conjugation (e.g., strain-promoted or copper-catalyzed azide–alkyne cycloaddition) to install or exchange targeting and warhead modules under conditions compatible with many PROTAC components. The PEG3 segment provides conformational flexibility and improves aqueous solubility, which can help maintain productive geometry between the recruited target-binding ligand and the E3 ligase-binding ligand during ternary complex formation. In targeted protein degradation workflows, this linker is valuable for modular PROTAC synthesis, allowing researchers to tune linker length and attachment chemistry while minimizing steric constraints that can reduce degradation potency.
Structure of 2054345-67-2
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Azide-PEG3-C1-Ala, is designed to provide a chemically addressable azide handle combined with a flexible polyethylene glycol spacer and an amino acid-derived moiety. Its features support efficient conjugation strategies that enable assembly of targeted protein degraders with controlled linker length and improved solubility. The azide functionality facilitates modular bioconjugation workflows, and the PEG-rich scaffold can help tune physicochemical properties. Detailed structural and synthetic guidance is provided below.
Structure: The linker contains an azide-bearing terminus attached to a PEG-based ether chain, coupled to an alanine-derived carbonyl-containing segment. It features ether linkages, amide functionality, and a terminal azide suitable for click-type transformations. Overall, it is an amphiphilic, flexible scaffold with enhanced aqueous compatibility.
Reactivity: The azide group is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling rapid formation of stable triazole linkages during PROTAC construction. Typical assembly uses inert, biocompatible solvents such as aqueous/organic mixtures, with copper catalysis requiring appropriate ligand and oxygen control to minimize side reactions. The PEG and amide components generally remain stable under standard conjugation conditions, supporting stepwise linker-to-ligand coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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