mPEG4-CH2CH2COONHS ester
CAS No.: 874208-94-3
Cat No.: BP-500791
Purity: >97%
4.5 
mPEG4-CH2CH2COONHS ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a short four–ethylene glycol unit chain terminated with an N-hydroxysuccinimide (NHS) ester. Structurally, it provides a PEG spacer for improved solubility and reduced nonspecific interactions, while the NHS-activated carboxyl group enables efficient amide-bond formation with primary amines on target-binding ligands (e.g., lysine-containing peptides or amine-functionalized small molecules) under standard aqueous coupling conditions. In PROTAC design, this linker is used to conjugate an amine-bearing component to a carboxyl-reactive handle, thereby positioning the two binding moieties with a defined, flexible distance and maintaining favorable geometry for ternary complex formation. Its PEGylated character can also help preserve the pharmacological-like properties of conjugates during synthesis and purification, making it a practical reagent for constructing degraders and for optimizing linker length and conjugation chemistry in targeted protein degradation research.
Structure of 874208-94-3
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This mPEG4-CH2CH2COONHS ester is a polyethylene glycol-based activated ester designed to serve as a PROTAC linker component for efficient conjugation chemistry. Its PEG segment provides solubility and reduced nonspecific interactions, while the NHS-activated carboxylate enables robust coupling to amine-bearing ligands under mild conditions. The resulting amide linkage formation supports modular PROTAC assembly, and the linker’s compatibility with common bioconjugation workflows will be described in detail below.
Structure: The molecule combines a methoxy-terminated PEG chain with an ethylene spacer and an NHS-activated carboxylate. It contains ether linkages within the PEG backbone and forms an activated ester functional group poised for nucleophilic acyl substitution, yielding stable amide bonds upon reaction with primary amines.
Reactivity: The NHS ester typically reacts with primary amines to form amide linkages via nucleophilic acyl substitution, with the NHS group serving as an leaving group. Suitable conditions generally use aqueous or mixed aqueous buffers at mildly basic pH, with light exclusion and temperature control to limit hydrolysis. Common solvents include water or alcohol-containing buffers, and no special catalysts are required beyond maintaining reagent compatibility and minimizing competing nucleophiles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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