Azido-PEG24-acid
Cat No.: BP-501828
4.5 
Azido-PEG24-acid is a heterobifunctional polyethylene glycol (PEG) linker bearing a terminal azide group and a carboxylic acid at the opposite end, providing a flexible, water-soluble chain of extended length for conjugation chemistry. The azide functionality enables efficient bioorthogonal coupling via copper-free click reactions (e.g., with strained alkynes) to attach the linker to PROTAC warheads, ligands, or reporter handles under conditions compatible with sensitive biomolecules. The terminal carboxylic acid can be activated for amide bond formation or used to introduce the linker into carboxylate-reactive coupling schemes, allowing modular assembly of degradation constructs. In PROTAC design, this type of PEG spacer helps tune the effective distance and relative orientation between the recruiting ligand and the target-binding moiety, which can improve productive ternary complex formation and mitigate steric constraints. Its long, flexible scaffold and orthogonal reactivity make it a valuable building block for optimizing targeted protein degradation reagents, including library synthesis and structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG24-acid is a polyethylene glycol (PEG)-based PROTAC linker bearing a terminal azide for reliable bioorthogonal conjugation and a carboxylic acid handle for controlled coupling to targeting ligands. Its flexible, hydrophilic PEG scaffold can improve solubility and modulate linker length and conformational freedom in ternary-complex forming degraders. The azide functionality enables standardized “click” chemistry workflows, and the subsequent sections describe the structure and practical reactivity considerations in detail below.
Structure: The linker consists of a repeating PEG ether chain terminating in an azide group and a carboxylic acid. It contains ether linkages that confer flexibility and hydrophilicity, alongside an azide moiety suitable for cycloaddition and a terminal carboxyl group capable of forming activated esters for amide bond formation.
Reactivity: The azide group is well suited to copper-catalyzed azide–alkyne cycloaddition with alkynes under commonly used click conditions, typically requiring a Cu(I) source and an appropriate reducing environment. The carboxylic acid can be converted to reactive intermediates (e.g., activated esters) using standard coupling reagents in polar aprotic solvents, enabling amide formation with amine-bearing ligands. Reaction design should consider aqueous compatibility and minimizing side reactions during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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