Biotin-PEG12-acid
CAS No.: 1621423-14-0
Cat No.: BP-500848
4.5 
Biotin-PEG12-acid is a heterobifunctional PEG-based linker featuring a terminal biotin moiety connected through a polyethylene glycol chain of twelve ethylene glycol units to a terminal carboxylic acid. The PEG spacer provides high aqueous solubility and flexibility, helping to reduce steric interference between the biotin ligand and the conjugated partner. In PROTAC and targeted degradation workflows, this linker is valuable as a handle for affinity-based capture or immobilization via streptavidin or avidin, enabling controlled assembly, purification, and characterization of biotin-tagged degraders or intermediate conjugates. The terminal carboxyl group allows straightforward coupling to amine- or hydrazide-containing ligands using standard amide or related chemistries, facilitating modular PROTAC construction. This product supports experimental designs that require reproducible attachment, enrichment, and downstream analysis of degradation systems while maintaining favorable biocompatible linker properties for biochemical assays.
Structure of 1621423-14-0
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Biotin-PEG12-acid is a polyethylene glycol-based linker designed to connect affinity ligands and support efficient targeted protein degradation workflows in PROTAC assemblies. Its PEG-rich scaffold provides conformational flexibility and improved solubility, helping maintain productive ternary complex formation. The terminal carboxylic acid enables reliable conjugation strategies with common PROTAC-relevant warheads or handles.
Structure: The linker comprises a biotin moiety tethered to a long PEG chain terminating in a carboxylic acid. It features ether linkages within the PEG segment and an acid functional group capable of forming amide or ester derivatives. Overall, it is a flexible, hydrophilic scaffold with enhanced aqueous compatibility.
Reactivity: The terminal carboxylic acid supports standard coupling reactions used in PROTAC construction, including amide bond formation with amine-bearing partners via carbodiimide-mediated activation. Typical approaches employ coupling reagents and base in polar organic solvents, followed by purification to remove excess reagents. Mechanistically, activation of the acid promotes nucleophilic acyl substitution by an amine to yield stable conjugates suitable for downstream degradation studies.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
