Biotin-PEG6-azide
CAS No.: 1085938-09-5
Cat No.: BP-501113
4.5 
Biotin-PEG6-azide is a heterobifunctional PEG-based linker that combines a biotin affinity handle with an azide functional group, providing a flexible, water-soluble tether for chemical conjugation. Structurally, it features a biotin moiety connected through a six-unit polyethylene glycol spacer to a terminal azide, which is well suited for copper-free or copper-catalyzed azide–alkyne cycloaddition (“click”) or for strain-promoted labeling strategies. In PROTAC and targeted protein degradation workflows, this linker can be used to attach biotin-tagged probes or affinity-capture elements to degraders, enabling streamlined detection, enrichment, and pull-down of ternary complexes or degradation intermediates when paired with biotin-binding reagents. Its PEG chain helps reduce steric interference and improves solubility, supporting robust conjugation and downstream analytical assays. Overall, it is a practical tool for researchers seeking modular, affinity-enabled characterization of PROTAC-mediated target engagement and degradation.
Structure of 1085938-09-5
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Biotin-PEG6-azide is a bifunctional PROTAC linker designed to combine a biotin handle with a PEG-based spacer and a terminal azide for modular conjugation. Its flexible poly(ethylene glycol) segment supports productive linker length and solubility, while the azide enables efficient click-type coupling to compatible partners. This makes the linker well suited for constructing targeted protein degradation reagents where controlled attachment chemistry is essential; detailed structural and reactivity considerations are provided below.
Structure: The linker contains a biotin moiety connected through a PEG-derived spacer to a terminal azide. It features ether linkages within the polyethylene glycol chain, an azide functional group, and amide/heteroatom-rich connectivity consistent with biotin. Overall polarity and conformational flexibility support aqueous compatibility.
Reactivity: The azide group is typically used in copper(I)-catalyzed azide–alkyne cycloaddition or related azide click reactions to form stable triazole linkages with alkyne-bearing ligands. Suitable conditions generally employ a Cu(I) source, an appropriate reducing environment, and polar solvents compatible with biomolecules. Reaction efficiency depends on ligand accessibility and maintaining mild temperatures to preserve sensitive targeting moieties.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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